Job Stress Strengthens the Link between Metabolic Risk Factors and Renal Dysfunction in Adult Men

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著者

    • TSURUGANO Shinobu
    • Department of Hygiene and Public Health, Teikyo University School of Medicine
    • NAKAO Mutsuhiro
    • Department of Hygiene and Public Health, Teikyo University School of Medicine
    • TAKEUCHI Takeaki
    • Department of Hygiene and Public Health, Teikyo University School of Medicine
    • NOMURA Kyoko
    • Department of Hygiene and Public Health, Teikyo University School of Medicine
    • YANO Eiji
    • Department of Hygiene and Public Health, Teikyo University School of Medicine

抄録

Chronic kidney disease (CKD) is an important risk factor for cardiovascular disease. The metabolic risk factors obesity, hypertension, diabetes, and dyslipidemia are closely associated with renal dysfunction. As psychosocial stress affects these risk factors, here, we examined relationships between metabolic risk factors and renal function, and their association with job stress. The participants were 1,231 Japanese male office workers attending annual health examinations. The estimated glomerular filtration rate (eGFR) was determined using the equation recommended by the Japanese Society for Nephrology: eGFR (mL/min/1.73 m<sup>2</sup>) = 194× age<sup>−0.287</sup> × Cr<sup>−1.094</sup>. Job stress was measured using the Job Content Questionnaire based on the job demand-control model. The job strain index equaled the job demand scores divided by the job control scores. The participants were classified into four ordinal groups of job strain index, based on previous studies (<i>i.e</i>., ≤ 0.4 the lowest, 0.4-0.5 lower, 0.5-0.6 higher, or ≥ 0.6 the highest). A significant correlation was found between lowered eGFR and each of the metabolic risk factors waist circumference, systolic and diastolic blood pressure, and total cholesterol (<i>p</i> < 0.001). Furthermore, job stress had an interactive effect on the relationships between eGFR and systolic and diastolic blood pressure, and triglycerides, depending on the job strain index (highest vs. lowest) (<i>p</i> < 0.05). The highly stressed workers exhibited a close association of eGFR with metabolic risk factors like hypertension and dyslipidemia. Therefore, intensive management may be important for preventing the progression of renal dysfunction and cardiovascular complications in those experiencing stress.

収録刊行物

  • Tohoku journal of experimental medicine

    Tohoku journal of experimental medicine 226(2), 101-108, 2012-02-01

    東北ジャーナル刊行会

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各種コード

  • NII論文ID(NAID)
    10030197051
  • NII書誌ID(NCID)
    AA00863920
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00408727
  • データ提供元
    CJP書誌  J-STAGE 
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