心不全モデル犬における持続性アンジオテンシンII受容体拮抗薬カンデサルタン・シレキセチル(TCV-116)の血行動態への影響 Effects of Candesartan Cilexetil (TCV-116), an Angiotensin Receptor Antagonist, on Hemodynamics in Experimental Model Dogs with Mitral Insufficiency

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<b>Objective :</b> Since the sensitivity to prostacyclin differs widely depending on the animal species, it is essential to investigate the dose setting from the safety point of view before using beraprost (BPS) in diseased cats.<br/><b>Design :</b> One week multiple administration toxicity study of BPS (10, 30, 70, 100 μg/kg, twice a day) compared with vehicle as control.<br/><b>Procedure :</b> BPS group (n=6) at 10, 30, 70 and 100 μg/kg and vehicle group (n=5) were administered to healthy cats twice a day for 7 days. Both in BPS and vehicle groups, cessation period of the drug was provided 2 weeks between each doses of BPS. In addition hemodynamic parameters were also noted at 0.5 hour before initial administration on the first day and at 1 hour after final administration on the 7th day of each dose of BPS and vehicle.<br/><b>Results :</b> Though BPS from 30 μg/kg upward transiently and dose-dependently increased the heart rate but had no influence on the blood pressure. Compared with the vehicle group, serum creatinine slightly but significantly decreased at 70 and 100 μg/kg and this decrease was also significant against the pre-administration value at the same dose. The influence of BPS on the blood parameters was nil or negligible, if any. Diarrhea were sporadically noted at 70 μg/kg, and mild and transient vomiting and sedation occurred at 100 μg/kg. However, each symptom soonerly disappeared without treatment.<br/><b>Conclusion :</b> The pharmacological action and types of adverse effects of BPS in the cats were almost similar to those observed in other animals and the repeated oral administration of BPS can be safely conducted in cats at least up to 30 μg/kg twice a day.

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  • 動物臨床医学 = Journal of Animal Clinical Research Foundation

    動物臨床医学 = Journal of Animal Clinical Research Foundation 12(3), 131-139, 2003-12-20

    Japanese Society of Clinical Veterinary Medicine

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