マウスボクセルファントムの電子吸収割合とS値 Electron Absorbed Fractions and S Values in a Voxel-based Mouse Phantom

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抄録

放射性医薬品の開発研究の一環として,モンテカルロ計算により,マウスボクセルファントムの電子吸収割合(AF)を評価した。線源は,10keVから4MeVの単色電子とし,臓器内均一分布とした。本研究により,臓器自己AFは,電子のエネルギーが線源臓器内において全て吸収されないこと,臓器間のAFは,電子エネルギー,線源と標的間の幾何学的条件に依存することを明らかにした。また,本研究では,<sup>131</sup>I,<sup>153</sup>Sm,<sup>188</sup>Re,<sup>90</sup>Yについて,マウス臓器S値を表にとりまとめた。

Electron absorbed fractions(AFs) and S values were evaluated in a voxel-based mouse phantom for preclinical evaluations of radiopharmaceuticals. The sources were considered monoenergetic in the electron energy range 10keV to 4MeV, and to be distributed uniformly with isotropic emission in the organs. The radiation transport was simulated using a Monte Carlo method. It was confirmed that electron AFs were dependent on the volume, density, and geometry of the source and target organs. The electron AFs for organ self-irradiation (i.e., the target is the source) decreased with increasing electron energy. The results from this study were consistent with other published data and indicated that the electron AF for self-irradiation was not always 1.0 and strongly depended on electron energy. The electron AFs for organ cross-fire (i.e., the target is not the source) were dependent on the electron energy emitted by the source and the geometries of source and target. Additionally, S values in the major organs of the voxel-based mouse phantom were tabulated for <sup>131</sup>I, <sup>153</sup>Sm, <sup>188</sup>Re, and <sup>90</sup>Y using the photon and electron AFs. The results of this study will be useful in determining organ doses in mice for radiopharmaceutical development.

収録刊行物

  • Radioisotopes

    Radioisotopes 60(12), 505-512, 2011-12-15

    Japan Radioisotope Association

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各種コード

  • NII論文ID(NAID)
    10030198357
  • NII書誌ID(NCID)
    AN00351589
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00338303
  • NDL 記事登録ID
    023383747
  • NDL 請求記号
    Z15-20
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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