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- Takagi Michiaki
- Department of Orthopaedic Surgery, Yamagata University School of Medicine
書誌事項
- タイトル別名
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- Toll-like Receptor -A Potent Driving Force behind Rheumatoid Arthritis-
- —A Potent Driving Force behind Rheumatoid Arthritis—
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抄録
Toll like receptor (TLR), one of the key functions of innate immune system, can recognize not only exogenous pathogen-associated molecular patterns, namely PAMPs, but also endogenous molecules created upon tissue injury, sterile inflammation and degeneration. Endogenous TLR ligands are called as damage-associated molecular patters (DAMPs), including endogenous molecules released by activated and necrotic cells, and extracellular matrix molecules. DAMPs are also known as alarmins. TLR research has brought about new insights in the rheumatic diseases. Previous reports suggest that TLRs and the signal pathways intensively contribute to the pathogenesis of rheumatoid arthritis (RA) and other arthritic conditions with interaction of various TLR ligands. Accumulated knowledge of TLR system is summarized to overlook TLRs and the signaling pathway in arthritis conditions, with special reference to RA. [J Clin Exp Hematopathol 51(2) : 77-92, 2011]
収録刊行物
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- Journal of Clinical and Experimental Hematopathology
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Journal of Clinical and Experimental Hematopathology 51 (2), 77-92, 2011
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詳細情報 詳細情報について
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- CRID
- 1390001204703195264
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- NII論文ID
- 10030207419
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- NII書誌ID
- AA11556796
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- ISSN
- 18809952
- 13464280
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可