Local Recurrence as Immunoglobulin G4 (IgG4)-Related Disease 10 Years after Radiotherapy to Ocular Adnexal Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue

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Author(s)

    • MATSUO Toshihiko
    • Department of Ophthalmology, Okayama University Medical School, and Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
    • ICHIMURA Kouichi
    • Department of Pathology, Okayama University Medical School, and Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
    • YOSHINO Tadashi
    • Department of Pathology, Okayama University Medical School, and Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

Abstract

In 2000, a 48-year-old woman developed a left orbital mass with lacrimal gland involvement and then, in 2003, a right orbital mass with lacrimal gland involvement, both of which were diagnosed as extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). She underwent 30 Gy external beam radiation to bilateral orbital lesions. The lymphoma cells in both lesions did not share the same clonality, as shown by amplification by polymerase chain reaction of the immunoglobulin heavy chain gene. Immunoglobulin light chain analysis by immunohistochemistry and messenger RNA <I>in situ</I> hybridization showed λ chain monotype in the left orbital lesion but κ chain monotype in the right orbital lesion. She developed recurrent left orbital mass with high uptake on fluorodeoxyglucose positron emission tomography fused with computed tomography in 2010, and excisional biopsy disclosed the formation of follicles and infiltration with immunoglobulin G4 (IgG4)-positive plasma cells mainly in interfollicular areas. The immunoglobulin light chain analysis showed the λ chain and κ chain bitype. With the immunohistopathological diagnosis of IgG4-related disease, the serum IgG4 level was found to show elevation at 376 mg/dL, and the patient chose observation. This is the first reported case of development of IgG4-related disease after bilataral orbital MALT lymphoma with external beam radiotherapy. [<I>J Clin Exp Hematopathol 51(2</I><I>) </I>: <I>125-133, 2011</I>]

Journal

  • Journal of Clinical and Experimental Hematopathology

    Journal of Clinical and Experimental Hematopathology 51(2), 125-133, 2011-11-01

    The Japanese Society for Lymphoreticular Tissue Research

References:  19

Cited by:  1

Codes

  • NII Article ID (NAID)
    10030207679
  • NII NACSIS-CAT ID (NCID)
    AA11556796
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13464280
  • Data Source
    CJP  CJPref  J-STAGE 
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