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- Lee Seounghee
- Health Promotion Center, Asan Medical Center, University of Ulsan College of Medicine Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University
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- Choe Jae-Won
- Health Promotion Center, Asan Medical Center, University of Ulsan College of Medicine
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- Kim Hong-Kyu
- Health Promotion Center, Asan Medical Center, University of Ulsan College of Medicine
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- Sung Joohon
- Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University
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Background: High-sensitivity C-reactive protein (hs-CRP) is a commonly used inflammatory marker. The association between hs-CRP and cancer is less consistent than that between hs-CRP and cardiovascular diseases. This study explored the association between hs-CRP and cancer, using a large database of Korean health examination records.<BR>Methods: A total of 80 781 Koreans who visited the health promotion center of a general hospital were included. There were 729 cases of cancer of any primary site during a 3-year period. Subjects with a known cancer or a condition capable of affecting hs-CRP were excluded.<BR>Results: Serum hs-CRP was significantly higher in cancer cases (2.9 mg/L) than in non-cases (1.4 mg/L; P < 0.0001). With the lowest hs-CRP category (<1 mg/L) as reference, the crude odds ratios (ORs) for cancer were 1.36 (95% confidence interval [CI] = 1.16–1.62) for the second highest category (1–3 mg/L) and 2.49 (95% CI = 2.02–3.07) for the highest category (>3 mg/L), and the adjusted ORs for cancer were 1.16 (95% CI = 0.95–1.42) for the second highest category and 1.94 (95% CI = 1.51–2.51) for the highest category. After excluding cancer cases detected within 1 year after the check-up, the associations remained, although the reduced number of cancer cases (n = 88) attenuated the significance of the associations.<BR>Conclusions: Serum hs-CRP was positively associated with the risk of cancer, although causality cannot be inferred in this cross-sectional study. The results support the hypothesis that chronic inflammation plays a role in cancer.
収録刊行物
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- Journal of Epidemiology
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Journal of Epidemiology 21 (3), 161-168, 2011
日本疫学会
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詳細情報 詳細情報について
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- CRID
- 1390282679453092736
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- NII論文ID
- 10030212575
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- NII書誌ID
- AA10952696
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- ISSN
- 13499092
- 09175040
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可