Profile of Participants and Genotype Distributions of 108 Polymorphisms in a Cross-Sectional Study of Associations of Genotypes With Lifestyle and Clinical Factors : A Project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study

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Author(s)

    • WAKAI Kenji
    • Department of Preventive Medicine, Nagoya University Graduate School of Medicine
    • HAMAJIMA Nobuyuki
    • Department of Preventive Medicine, Nagoya University Graduate School of Medicine
    • OKADA Rieko
    • Department of Preventive Medicine, Nagoya University Graduate School of Medicine
    • NAITO Mariko
    • Department of Preventive Medicine, Nagoya University Graduate School of Medicine
    • MORITA Emi
    • Department of Preventive Medicine, Nagoya University Graduate School of Medicine
    • HISHIDA Asahi
    • Department of Preventive Medicine, Nagoya University Graduate School of Medicine
    • KAWAI Sayo
    • Department of Preventive Medicine, Nagoya University Graduate School of Medicine
    • NISHIO Kazuko
    • Department of Preventive Medicine, Nagoya University Graduate School of Medicine
    • YIN Guang
    • Department of Preventive Medicine, Nagoya University Graduate School of Medicine
    • MATSUO Keitaro
    • Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
    • HOSONO Satoyo
    • Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
    • ITO Hidemi
    • Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
    • WATANABE Miki
    • Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
    • KAWASE Takakazu
    • Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
    • SUZUKI Takeshi
    • Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Science
    • TANAKA Keitaro
    • Department of Preventive Medicine, Faculty of Medicine, Saga University
    • HIGAKI Yasuki
    • Laboratory of Exercise Physiology, Faculty of Sports and Health Science, Fukuoka University
    • HARA Megumi
    • Department of Preventive Medicine, Faculty of Medicine, Saga University
    • IMAIZUMI Takeshi
    • Department of Preventive Medicine, Faculty of Medicine, Saga University
    • TAGUCHI Naoto
    • Department of Preventive Medicine, Faculty of Medicine, Saga University
    • NAKAMURA Kazuyo
    • Department of Preventive Medicine, Faculty of Medicine, Saga University
    • NANRI Hinako
    • Department of Preventive Medicine, Faculty of Medicine, Saga University
    • HORITA Mikako
    • Department of Preventive Medicine, Faculty of Medicine, Saga University
    • SHINCHI Koichi
    • Division of International Health and Nursing, Faculty of Medicine, Saga University
    • KITA Yoshikuni
    • Department of Health Science, Shiga University of Medical Science
    • RUMANA Nahid
    • Department of Health Science, Shiga University of Medical Science
    • MATSUI Kenji
    • Department of Health Science, Shiga University of Medical Science
    • TAKASHIMA Naoyuki
    • Lifestyle-Related Disease Prevention Center, Shiga University of Medical Science
    • SUZUKI Sadao
    • Department of Public Health, Nagoya City University Graduate School of Medical Sciences
    • ANDO Ryosuke
    • Department of Public Health, Nagoya City University Graduate School of Medical Sciences
    • HOSONO Akihiro
    • Department of Public Health, Nagoya City University Graduate School of Medical Sciences
    • IMAEDA Nahomi
    • Department of Public Health, Nagoya City University Graduate School of Medical Sciences
    • SHIBATA Kiyoshi
    • Department of Public Health, Nagoya City University Graduate School of Medical Sciences
    • GOTO Chiho
    • Department of Public Health, Nagoya City University Graduate School of Medical Sciences
    • HATTORI Nami
    • Department of Public Health, Nagoya City University Graduate School of Medical Sciences
    • TOKUDOME Shinkan
    • Department of Public Health, Nagoya City University Graduate School of Medical Sciences
    • TAKEZAKI Toshiro
    • Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science
    • NIIMURA Hideshi
    • Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science
    • HIRASADA Kazuyo
    • Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science
    • NAKAMURA Akihiko
    • Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science
    • TATEBO Masaya
    • Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science
    • OGAWA Shin
    • Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science
    • TSUNEMATSU Noriko
    • Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science
    • CHIBA Shirabe
    • Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science
    • MIKAMI Haruo
    • Division of Cancer Registry, Prevention and Epidemiology, Chiba Cancer Center
    • KONO Suminori
    • Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University
    • OHNAKA Keizo
    • Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University
    • TAKAYANAGI Ryoichi
    • Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
    • WATANABE Yoshiyuki
    • Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
    • OZAKI Etsuko
    • Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
    • SHIGETA Masako
    • Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
    • KURIYAMA Nagato
    • Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
    • YOSHIKAWA Aya
    • Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
    • MATSUI Daisuke
    • Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
    • WATANABE Isao
    • Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
    • INOUE Kaoru
    • Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
    • OZASA Kotaro
    • Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
    • MITANI Satoko
    • Unit for Liveable Cities, Graduate School of Medicine, Kyoto University
    • ARISAWA Kokichi
    • Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • UEMURA Hirokazu
    • Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • HIYOSHI Mineyoshi
    • Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • TAKAMI Hidenobu
    • Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • YAMAGUCHI Miwa
    • Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • NAKAMOTO Mariko
    • Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • TAKEDA Hideo
    • Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • KUBO Michiaki
    • Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN
    • TANAKA Hideo
    • Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute

Abstract

<b>Background: </b>Most diseases are thought to arise from interactions between environmental factors and the host genotype. To detect gene–environment interactions in the development of lifestyle-related diseases, and especially cancer, the Japan Multi-institutional Collaborative Cohort (J-MICC) Study was launched in 2005.<BR><b>Methods: </b>We initiated a cross-sectional study to examine associations of genotypes with lifestyle and clinical factors, as assessed by questionnaires and medical examinations. The 4519 subjects were selected from among participants in the J-MICC Study in 10 areas throughout Japan. In total, 108 polymorphisms were chosen and genotyped using the Invader assay.<BR><b>Results: </b>The study group comprised 2124 men and 2395 women with a mean age of 55.8 ± 8.9 years (range, 35–69 years) at baseline. Among the 108 polymorphisms examined, 4 were not polymorphic in our study population. Among the remaining 104 polymorphisms, most variations were common (minor allele frequency ≥0.05 for 96 polymorphisms). The allele frequencies in this population were comparable with those in the HapMap-JPT data set for 45 Japanese from Tokyo. Only 5 of 88 polymorphisms showed allele-frequency differences greater than 0.1. Of the 108 polymorphisms, 32 showed a highly significant difference in minor allele frequency among the study areas (<i>P</i> < 0.001).<BR><b>Conclusions: </b>This comprehensive data collection on lifestyle and clinical factors will be useful for elucidating gene–environment interactions. In addition, it is likely to be an informative reference tool, as free access to genotype data for a large Japanese population is not readily available.

Journal

  • Journal of Epidemiology

    Journal of Epidemiology 21(3), 223-235, 2011-05-01

    Japan Epidemiological Association

References:  22

Cited by:  3

Codes

  • NII Article ID (NAID)
    10030212853
  • NII NACSIS-CAT ID (NCID)
    AA10952696
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    09175040
  • Data Source
    CJP  CJPref  J-STAGE 
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