Profile of Participants and Genotype Distributions of 108 Polymorphisms in a Cross-Sectional Study of Associations of Genotypes With Lifestyle and Clinical Factors: A Project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study

Wakai Kenji, Hamajima Nobuyuki, Okada Rieko, Naito Mariko, Morita Emi, Hishida Asahi, Kawai Sayo, Nishio Kazuko, Yin Guang, Asai Yatami, Matsuo Keitaro, Hosono Satoyo, Ito Hidemi, Watanabe Miki, Kawase Takakazu, Suzuki Takeshi, Tajima Kazuo, Tanaka Keitaro, Higaki Yasuki, Hara Megumi, Imaizumi Takeshi, Taguchi Naoto, Nakamura Kazuyo, Nanri Hinako, Sakamoto Tatsuhiko, Horita Mikako, Shinchi Koichi, Kita Yoshikuni, Turin Tanvir Chowdhury, Rumana Nahid, Matsui Kenji, Miura Katsuyuki, Ueshima Hirotsugu, Takashima Naoyuki, Nakamura Yasuyuki, Suzuki Sadao, Ando Ryosuke, Hosono Akihiro, Imaeda Nahomi, Shibata Kiyoshi, Goto Chiho, Hattori Nami, Fukatsu Mitsuru, Yamada Tamaki, Tokudome Shinkan, Takezaki Toshiro, Niimura Hideshi, Hirasada Kazuyo, Nakamura Akihiko, Tatebo Masaya, Ogawa Shin, Tsunematsu Noriko, Chiba Shirabe, Mikami Haruo, Kono Suminori, Ohnaka Keizo, Takayanagi Ryoichi, Watanabe Yoshiyuki, Ozaki Etsuko, Shigeta Masako, Kuriyama Nagato, Yoshikawa Aya, Matsui Daisuke, Watanabe Isao, Inoue Kaoru, Ozasa Kotaro, Mitani Satoko, Arisawa Kokichi, Uemura Hirokazu, Hiyoshi Mineyoshi, Takami Hidenobu, Yamaguchi Miwa, Nakamoto Mariko, Takeda Hideo, Kubo Michiaki, Tanaka Hideo

doi:10.2188/jea.je20100139

Background: Most diseases are thought to arise from interactions between environmental factors and the host genotype. To detect gene–environment interactions in the development of lifestyle-related diseases, and especially cancer, the Japan Multi-institutional Collaborative Cohort (J-MICC) Study was launched in 2005.<BR>Methods: We initiated a cross-sectional study to examine associations of genotypes with lifestyle and clinical factors, as assessed by questionnaires and medical examinations. The 4519 subjects were selected from among participants in the J-MICC Study in 10 areas throughout Japan. In total, 108 polymorphisms were chosen and genotyped using the Invader assay.<BR>Results: The study group comprised 2124 men and 2395 women with a mean age of 55.8 ± 8.9 years (range, 35–69 years) at baseline. Among the 108 polymorphisms examined, 4 were not polymorphic in our study population. Among the remaining 104 polymorphisms, most variations were common (minor allele frequency ≥0.05 for 96 polymorphisms). The allele frequencies in this population were comparable with those in the HapMap-JPT data set for 45 Japanese from Tokyo. Only 5 of 88 polymorphisms showed allele-frequency differences greater than 0.1. Of the 108 polymorphisms, 32 showed a highly significant difference in minor allele frequency among the study areas (P < 0.001).<BR>Conclusions: This comprehensive data collection on lifestyle and clinical factors will be useful for elucidating gene–environment interactions. In addition, it is likely to be an informative reference tool, as free access to genotype data for a large Japanese population is not readily available.

Profile of Participants and Genotype Distributions of 108 Polymorphisms in a Cross-Sectional Study of Associations of Genotypes With Lifestyle and Clinical Factors: A Project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study

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Profile of Participants and Genotype Distributions of 108 Polymorphisms in a Cross-Sectional Study of Associations of Genotypes With Lifestyle and Clinical Factors: A Project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study

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