Effects of Maternal 5, 10-Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Tobacco Smoking on Infant Birth Weight in a Japanese Population

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Author(s)

    • YILA Thamar Ayo
    • Department of Public Health Sciences, Hokkaido University Graduate School of Medicine
    • SASAKI Seiko
    • Department of Public Health Sciences, Hokkaido University Graduate School of Medicine
    • MIYASHITA Chihiro
    • Department of Public Health Sciences, Hokkaido University Graduate School of Medicine
    • KASHINO Ikuko
    • Department of Public Health Sciences, Hokkaido University Graduate School of Medicine
    • KOBAYASHI Sumitaka
    • Department of Public Health Sciences, Hokkaido University Graduate School of Medicine
    • OKADA Emiko
    • Department of Public Health Sciences, Hokkaido University Graduate School of Medicine
    • BABA Toshiaki
    • Department of Public Health Sciences, Hokkaido University Graduate School of Medicine
    • YOSHIOKA Eiji
    • Department of Public Health Sciences, Hokkaido University Graduate School of Medicine
    • MINAKAMI Hisanori
    • Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine
    • ENDO Toshiaki
    • Department of Obstetrics and Gynecology, School of Medicine, Sapporo Medical University
    • SENGOKU Kazuo
    • Department of Obstetrics and Gynecology, School of Medicine, Asahikawa Medical College
    • KISHI Reiko
    • Center for Environmental and Health Sciences, Hokkaido University

Abstract

<b>Background: </b>Intracellular folate hemostasis depends on the 5,10-methylenetetrahydrofolate reductase (<i>MTHFR</i>) gene. Because 5,10-<i>MTHFR</i> 677TT homozygosity and tobacco smoking are associated with low folate status, we tested the hypothesis that smoking in mothers with 5,10-<i>MTHFR</i> C677T or A1298C polymorphisms would be independently associated with lower birth weight among their offspring.<BR><b>Methods: </b>We assessed 1784 native Japanese mother-child pairs drawn from the ongoing birth cohort of The Hokkaido Study on Environment and Children’s Health. Data (demographic information, hospital birth records, and biological specimens) were extracted from recruitments that took place during the period from February 2003 to March 2006. Maternal serum folate were assayed by chemiluminescent immunoassay, and genotyping of 5,10-<i>MTHFR</i> C677T/A1298C polymorphisms was done using a TaqMan allelic discrimination assay.<BR><b>Results: </b>The prevalence of folate deficiency (<6.8 nmol/L) was 0.3%. The 5,10-<i>MTHFR</i> 677CT genotype was independently associated with an increase of 36.40 g (95% CI: 2.60 to 70.30, <i>P</i> = 0.035) in mean infant birth weight and an increase of 90.70 g (95% CI: 6.00 to 175.50, <i>P</i> = 0.036) among male infants of nonsmokers. Female infants of 677TT homozygous passive smokers were 99.00 g (95% CI: −190.26 to −7.56, <i>P</i> = 0.034) lighter. The birth weight of the offspring of smokers with 5,10-<i>MTHFR</i> 1298AA homozygosity was lower by 107.00 g (95% CI: −180.00 to −33.90, <i>P</i> = 0.004).<BR><b>Conclusions: </b>The results suggest that, in this population, maternal 5,10-<i>MTHFR</i> C677T polymorphism, but not the 5,10-<i>MTHFR</i> A1298C variant, is independently associated with improvement in infant birth weight, especially among nonsmokers. However, 5,10-<i>MTHFR</i> 1298AA might be associated with folate impairment and could interact with tobacco smoke to further decrease birth weight.

Journal

  • Journal of Epidemiology

    Journal of Epidemiology 22(2), 91-102, 2012-03-01

    Japan Epidemiological Association

References:  60

Codes

  • NII Article ID (NAID)
    10030213303
  • NII NACSIS-CAT ID (NCID)
    AA10952696
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    09175040
  • Data Source
    CJP  IR  J-STAGE 
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