Fe3O4/<i>o</i>-Carboxymethyl Chitosan/Curcumin-based Nanodrug System for Chemotherapy and Fluorescence Imaging in HT29 Cancer Cell Line

• Ha Phuong Thu

  Institute of Materials Science

• Le Thi Thu Huong

  Hanoi University of Agriculture

• Hoang Thi My Nhung

  Hanoi University of Science, Vietnam National University

• Nguyen Thi Tham

  Hanoi University of Science, Vietnam National University

• Nguyen Dac Tu

  Hanoi University of Science, Vietnam National University

• Ha Thi Minh Thi

  Hue University of Medicine and Pharmacy

• Pham Thi Bich Hanh

  Institute of Chemistry, Vietnam Academy of Science and Technology

• Tran Thi Minh Nguyet

  Institute of Materials Science

• Nguyen Thi Quy

  Hanoi University of Science, Vietnam National University

• Pham Hong Nam

  Institute of Materials Science

• Tran Dai Lam

  Institute of Materials Science

• Nguyen Xuan Phuc

  Institute of Materials Science

• Duong Tuan Quang

  Department of Chemistry, Hue University

抄録

A multifunctional nanodrug system containing Fe3O4, o-carboxymethyl chitosan (OCMCs), and curcumin (Cur) has been prepared and characterized by infrared and fluorescence spectroscopy, X-ray diffraction (XRD), and field-emission scanning electron microscopy (FE-SEM). The fluorescent staining experiments showed that this system not only had no effect on the cell internalization ability of curcumin but also successfully led curcumin into the HT29 cells as expected. From real-time cell analysis (RTCA), the effect of Fe3O4/OCMCs/Cur on this cancer cell line was found to be much stronger than that of pure curcumin. This system contained magnetic particles and, therefore, could be also considered for hyperthermia therapy in cancer treatment.

収録刊行物

• Chemistry Letters

  Chemistry Letters 40 (11), 1264-1266, 2011-10-15

  Oxford University Press (OUP)

キーワード

• General Chemistry

詳細情報

• CRID: 1360565169064920960
• NII論文ID: 10030220182
• NII書誌ID: AA00603318
• DOI: 10.1246/cl.2011.1264
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/40/11/1264/55605975/cl.2011.1264.pdf
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