Synthesis and Enhanced Radical Scavenging Activity of a Conformationally Constrained Epigallocatechin Analogue

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著者

    • IMAI Kohei
    • Division of Organic Chemistry, National Institute of Health Sciences
    • NAKANISHI Ikuo
    • Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
    • ANZAI Kazunori
    • Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
    • OZAWA Toshihiko
    • Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
    • MIYATA Naoki
    • Division of Organic Chemistry, National Institute of Health Sciences
    • URANO Shiro
    • Department of Bioscience and Engineering, Shibaura Institute of Technology
    • OKUDA Haruhiro
    • Division of Organic Chemistry, National Institute of Health Sciences
    • NAKAMURA Asao
    • Department of Applied Chemistry, Shibaura Institute of Technology

抄録

The freely rotating single bond between the pyrogallol and chroman substructures in epigallocatechin (EGC) was constrained by reaction of EGC with acetone in the presence of trimethylsilyl trifluoromethanesulfonate to prepare the rigidified analog in good yield. The synthesized analog was examined for free radical scavenging activity toward the galvinoxyl radical and was found to be 27-fold more potent than EGC.

収録刊行物

  • Chemistry letters

    Chemistry letters 40(12), 1417-1419, 2011-12-05

    公益社団法人 日本化学会

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各種コード

  • NII論文ID(NAID)
    10030221524
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
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