Virus Capsid Coating of Gold Nanoparticles via Cysteine-Au Interactions and Their Effective Cellular Uptakes

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著者

    • NAGAKAWA Keita
    • Department of Chemistry, Graduate School of Science, Hokkaido University
    • SUZUKI Tadaki
    • Research Center for Zoonosis Control and Global COE program, Hokkaido University
    • IGARASHI Manabu
    • Research Center for Zoonosis Control and Global COE program, Hokkaido University
    • SAWA Hirofumi
    • Research Center for Zoonosis Control and Global COE program, Hokkaido University

抄録

This manuscript describes the synthesis of virus capsid protein-coated Au nanoparticle (VP–AuNP) without the use of the inherent self-assembly of virus proteins into virus particles. Covalent binding between Au and cysteines in the virus proteins keep the cell-surface binding sites on the external surface. Based on this method, various sizes of VP–AuNP can be created in a similar manner to native virus particles. We clarified the optimum size of the VP–AuNP for internalization into cells.

収録刊行物

  • Chemistry letters

    Chemistry letters 41(1), 113-115, 2012-01-05

    公益社団法人 日本化学会

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各種コード

  • NII論文ID(NAID)
    10030222850
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
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