上顎歯肉と硬口蓋の壊死性潰瘍を伴った節外性NK/T細胞リンパ腫, 鼻型の1例 A case of extranodal NK/T cell lymphoma, nasal type with a necrotic ulcer in the upper gingiva and hard palate

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著者

    • 金子 貴広 KANEKO Takahiro
    • 埼玉医科大学総合医療センター 歯科口腔外科 Department of Oral and Maxillofacial Surgery, Saitama Medical Center, Saitama Medical University
    • 増田 一生 MASUDA Issei
    • 埼玉医科大学総合医療センター 歯科口腔外科 Department of Oral and Maxillofacial Surgery, Saitama Medical Center, Saitama Medical University
    • 川野 竜太郎 [他] KAWANO Ryutaro
    • 埼玉医科大学総合医療センター 歯科口腔外科 Department of Oral and Maxillofacial Surgery, Saitama Medical Center, Saitama Medical University
    • 那須 大介 NASU Daisuke
    • 埼玉医科大学総合医療センター 歯科口腔外科 Department of Oral and Maxillofacial Surgery, Saitama Medical Center, Saitama Medical University
    • 堀江 憲夫 HORIE Norio
    • 埼玉医科大学総合医療センター 歯科口腔外科 Department of Oral and Maxillofacial Surgery, Saitama Medical Center, Saitama Medical University
    • 下山 哲夫 SHIMOYAMA Tetsuo
    • 埼玉医科大学総合医療センター 歯科口腔外科 Department of Oral and Maxillofacial Surgery, Saitama Medical Center, Saitama Medical University

抄録

Extranodal NK/T cell lymphoma, nasal type rarely arises in the oral cavity. We report the case of a 55 year-old man who was referred to our hospital because of facial swelling. At presentation, a necrotizing ulcer was found on the left side of the anterior palatal gingiva. Computed tomography showed a soft tissue density in the left sinus, but no evidence of bone destruction. Because the necrotizing ulcer expanded rapidly for a few days, a malignant tumor was suspected. Immunohistochemical analyses of a biopsy specimen revealed that the tumor cells were positive for CD3ε, CD56, granzyme B, perforin, and TIA-1, and negative for CD20, CD79a, and AE1/AE3. Epstein-Barr virus-encoded small RNA -1 was detected on <i>in situ </i>hybridization. Based on these findings, the patient was given a diagnosis of extranodal NK/T cell lymphoma, nasal type. The patient received chemoradiotherapy. Treatment was effective, and a complete response was obtained temporarily. However, recurrence occurred, and the patient received secondary chemotherapy with CHOP and allogeneic hematopoietic stem cell transplantation. Thereafter, his general condition deteriorated rapidly, and the patient died approximately 3 months after recurrence.

Extranodal NK/T cell lymphoma, nasal type rarely arises in the oral cavity. We report the case of a 55 year-old man who was referred to our hospital because of facial swelling. At presentation, a necrotizing ulcer was found on the left side of the anterior palatal gingiva. Computed tomography showed a soft tissue density in the left sinus, but no evidence of bone destruction. Because the necrotizing ulcer expanded rapidly for a few days, a malignant tumor was suspected. Immunohistochemical analyses of a biopsy specimen revealed that the tumor cells were positive for CD3ε, CD56, granzyme B, perforin, and TIA-1, and negative for CD20, CD79a, and AE1/AE3. Epstein-Barr virus-encoded small RNA -1 was detected on <i>in situ </i>hybridization. Based on these findings, the patient was given a diagnosis of extranodal NK/T cell lymphoma, nasal type. The patient received chemoradiotherapy. Treatment was effective, and a complete response was obtained temporarily. However, recurrence occurred, and the patient received secondary chemotherapy with CHOP and allogeneic hematopoietic stem cell transplantation. Thereafter, his general condition deteriorated rapidly, and the patient died approximately 3 months after recurrence.

収録刊行物

  • 日本口腔外科学会雑誌

    日本口腔外科学会雑誌 57(5), 284-288, 2011-05-20

    社団法人 日本口腔外科学会

参考文献:  23件中 1-23件 を表示

各種コード

  • NII論文ID(NAID)
    10030272020
  • NII書誌ID(NCID)
    AN00189163
  • 本文言語コード
    JPN
  • 資料種別
    NOT
  • ISSN
    00215163
  • NDL 記事登録ID
    11131952
  • NDL 雑誌分類
    ZS44(科学技術--医学--歯科学・口腔外科学)
  • NDL 請求記号
    Z19-145
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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