初期臨床像を観察し得た口蓋歯肉原発節外性NK/T細胞リンパ腫, 鼻型の1例 A case of primary extranodal NK/T-cell lymphoma, nasal type of the palatal gingiva, able to be observed from the earliest clinical features

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著者

    • 神津 由直 KOUZU Yukinao
    • 千葉大学医学部附属病院歯科・顎・口腔外科 Division of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital
    • 山本 亞有美 YAMAMOTO Ayumi
    • 千葉大学医学部附属病院歯科・顎・口腔外科 Division of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital
    • 椎葉 正史 SHIIBA Masashi
    • 千葉大学医学部附属病院歯科・顎・口腔外科 Division of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital
    • 鵜澤 一弘 UZAWA Katsuhiro
    • 千葉大学医学部附属病院歯科・顎・口腔外科 Division of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital
    • 丹沢 秀樹 TANZAWA Hideki
    • 千葉大学医学部附属病院歯科・顎・口腔外科 Division of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital

抄録

Extranodal natural killer/T-cell lymphoma, nasal type (ENKL) characterized by a necrotizing ulcer is an uncommon malignant lymphoma thought to be associated with Epstein-Barr virus infection and expression of CD56. We report a case of ENKL that could be observed from the earliest clinical features of the palatal gingiva. A 27-year-old-woman was referred to our hospital because of painful purpura-like lesions in the left side of the palatal gingiva. The purpura-like lesions developed to a necrotizing ulcer in about 1 week. Microscopic examination of a biopsy specimen demonstrated a lymphocytic infiltrate with increasingly atypical histopathological features. The atypical cells were positive for cytoplasmic CD3ε, granzyme B, and EBER-ISH, but negative for CD20 and CD56. Based on the histopathological findings, a final diagnosis of ENKL was made. The patient received radiotherapy to a dose of 50 Gy and three courses of DeVIC (CBDCA, VP-16, IFO, DEX) chemotherapy. There has been no sign of recurrence for 32 months after treatment. This case shows that purpura-like lesions might be one of the earliest clinical features of ENKL.

Extranodal natural killer/T-cell lymphoma, nasal type (ENKL) characterized by a necrotizing ulcer is an uncommon malignant lymphoma thought to be associated with Epstein-Barr virus infection and expression of CD56. We report a case of ENKL that could be observed from the earliest clinical features of the palatal gingiva. A 27-year-old-woman was referred to our hospital because of painful purpura-like lesions in the left side of the palatal gingiva. The purpura-like lesions developed to a necrotizing ulcer in about 1 week. Microscopic examination of a biopsy specimen demonstrated a lymphocytic infiltrate with increasingly atypical histopathological features. The atypical cells were positive for cytoplasmic CD3ε, granzyme B, and EBER-ISH, but negative for CD20 and CD56. Based on the histopathological findings, a final diagnosis of ENKL was made. The patient received radiotherapy to a dose of 50 Gy and three courses of DeVIC (CBDCA, VP-16, IFO, DEX) chemotherapy. There has been no sign of recurrence for 32 months after treatment. This case shows that purpura-like lesions might be one of the earliest clinical features of ENKL.

収録刊行物

  • 日本口腔外科学会雑誌

    日本口腔外科学会雑誌 57(11), 610-614, 2011-11-20

    社団法人 日本口腔外科学会

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各種コード

  • NII論文ID(NAID)
    10030273143
  • NII書誌ID(NCID)
    AN00189163
  • 本文言語コード
    JPN
  • 資料種別
    NOT
  • ISSN
    00215163
  • NDL 記事登録ID
    023331195
  • NDL 請求記号
    Z19-145
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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