Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome

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著者

    • YOKOTA Takashi
    • Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    • KINUGAWA Shintaro
    • Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    • OKITA Koichi
    • Graduate School of Program in Lifelong Learning Studies, Hokusho University
    • HIRABAYASHI Kagami
    • Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    • SUGA Tadashi
    • Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    • OYAMA MANABE Noriko
    • Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital
    • SHIRATO Hiroki
    • Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital
    • TSUTSUI Hiroyuki
    • Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

抄録

Lower aerobic capacity is a strong and independent predictor of cardiovascular morbidity and mortality in patients with metabolic syndrome (MetS). However, the mechanisms are not fully elucidated. We tested the hypothesis that skeletal muscle dysfunction could contribute to the lower aerobic capacity in MetS patients. The incremental exercise tests with cycle ergometer were performed in 12 male patients with MetS with no habitual exercise and 11 age-, sex-, and activity-matched control subjects to assess the aerobic capacity. We performed 31phosphorus-magnetic resonance spectroscopy (31P-MRS) to assess the high-energy phosphate metabolism in skeletal muscle during aerobic exercise. Proton(1H)-MRS was also performed to measure intramyocellular lipid (IMCL) content. Peak oxygen uptake (peak VO2; 34.1 ± 6.2 vs. 41.4 ± 8.4 mL/kg/min, P < 0.05) and anaerobic threshold (AT; 18.0 ± 2.4 vs. 23.1 ± 3.7 mL/kg/min, P < 0.01) adjusted by lean body mass were lower in MetS patients than control subjects. Phosphocreatine (PCr) loss during exercise was 1.5-fold greater in MetS, suggesting reduced intramuscular oxidative capacity. PCr loss was inversely correlated with peak VO2 (r = -0.64) and AT (r = -0.60), respectively. IMCL content was 3-fold higher in MetS and was inversely correlated with peak VO2 (r = -0.47) and AT (r = -0.52), respectively. Moreover, there was a positive correlation between IMCL content and PCr loss (r = 0.64). These results suggested that lean-body aerobic capacity in MetS patients was lower compared with activity-matched healthy subjects, which might be due to the reduced intramuscular fatty acid oxidative metabolism.

収録刊行物

  • Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension

    Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 34(9), 1029-1034, 2011-09-01

    Nature Publishing Group

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各種コード

  • NII論文ID(NAID)
    10030276102
  • NII書誌ID(NCID)
    AA10847079
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09169636
  • データ提供元
    CJP書誌  CJP引用  IR 
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