オゾンジェルの歯内治療領域への応用 : 殺菌効果および細胞傷害性の検討 Study on the use of an ozone gel for endodontic therapy : Bactericidal and cytotoxic effects

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著者

    • 加藤 友規 KATOH Yuuki
    • 愛知学院大学歯学部歯内治療学講座 Department of Endodontics, Aichi Gakuin University, School of Dentistry
    • 堀場 直樹 HORIBA Naoki
    • 愛知学院大学歯学部歯内治療学講座 Department of Endodontics, Aichi Gakuin University, School of Dentistry
    • 松本 享 MATSUMOTO Toru
    • 愛知学院大学歯学部歯内治療学講座 Department of Endodontics, Aichi Gakuin University, School of Dentistry
    • 中村 洋 NAKAMURA Hiroshi
    • 愛知学院大学歯学部歯内治療学講座 Department of Endodontics, Aichi Gakuin University, School of Dentistry

抄録

<p><b>Abstract : </b>The purpose of this study was to examine any bactericidal and/or cytotoxic effects stemming from an ozone gel and from this determine whether it is possible to incorporate ozone into glycerin for intracanal treatment. When 100 ppm of an ozone gel prepared immediately after thawing was applied for 10 minutes to root canals containing bacteria, the number of viable bacteria decreased below a detectable limit for three species ; <i>E. coli</i> K-12, <i>S. aureus</i>, <i>and L. casei</i> (excluding <i>E. faecalis</i>). A ninety-eight percent glycerin solution did not show any bactericidal effects. With regard to any bactericidal effects of an ozone gel prepared 28 days after thawing, it was observed that the number of viable bacteria decreased from 10<sup>7</sup> to 10<sup>2</sup> cfu/mL. With regard to any bactericidal effects from bacteria in quasi-infected root canals, it was observed that the number of viable bacteria decreased below a detectable limit after application of an ozone gel in four of the five root canals in which <i>E. coli</i> K-12 was applied, or in three of those canals in which <i>E. faecalis</i> was applied. Twenty-four hours after application, the number of viable bacteria decreased below a detectable limit in two of the root canals in which <i>E. coli</i> K-12 or <i>E. faecalis</i> were applied, respectively. With regard to any cytotoxicity of the ozone gel, it was observed that when the volume of the medium was 2.0 mL, there was no significant difference between the experimental and control groups. When the volume of the medium was 100 μL, a significant difference was observed between the experimental and control groups (p<0.01). These results suggest that ozone gel may be useful as an intracanal medication for the treatment of infected root canals.</p>

収録刊行物

  • 日本歯内療法学会雑誌 = The journal of Japan Endodontic Association

    日本歯内療法学会雑誌 = The journal of Japan Endodontic Association 33(1), 20-28, 2012-01-31

    一般社団法人 日本歯内療法学会

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各種コード

  • NII論文ID(NAID)
    10030283625
  • NII書誌ID(NCID)
    AA11837117
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    13478672
  • データ提供元
    CJP書誌  J-STAGE 
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