Effective Performance of T_1-weighted FLAIR Imaging with BLADE in Pediatric Brains





Purpose: In magnetic resonance imaging of the brain, BLADE is used to compensate for head motion. The technique focuses mainly on acquisition of T<sub>2</sub>-weighted or contrast-enhanced T<sub>1</sub>-weighted images in adults; its utility for nonenhanced T<sub>1</sub>-weighted imaging in children is not well established. We compared the quality of T<sub>1</sub>-weighted fluid-attenuated inversion recovery brain imaging with BLADE (T<sub>1</sub>-FLAIR-BLADE) to that of conventional spin-echo T<sub>1</sub>-weighted imaging (T<sub>1</sub>-SE) in pediatric patients who cannot stay still during MR imaging.<br> Materials and Methods: Our investigation included a volunteer study and a retrospective clinical study. Six healthy adult volunteers underwent scanning to compare the contrast of T<sub>1</sub>-SE, T<sub>1</sub>-weighted fluid-attenuated inversion recovery imaging (T<sub>1</sub>-FLAIR), and T<sub>1</sub>-FLAIR-BLADE at both 1.5 and 3 tesla. Comparison was based on scores assigned independently by 2 blinded observers and by calculated contrast-to-noise ratio. The clinical study included 20 children who underwent both T<sub>1</sub>-SE and T<sub>1</sub>-FLAIR-BLADE at either 1.5 (n=9) or 3 T (n=11). On each sequence, 2 blinded observers independently scored visualization of the cerebral gyri and contrast between gray and white matter. We compared scores between sequences separately for 1.5 and 3T using Wilcoxon signed-rank tests.<br> Results: At both 1.5 and 3T, contrast was better using T<sub>1</sub>-FLAIR and T<sub>1</sub>-FLAIR-BLADE than T<sub>1</sub>-SE in volunteers, and overall scores were significantly higher with T<sub>1</sub>-FLAIR-BLADE (<i>P</i><0.05) than T<sub>1</sub>-SE in the clinical study.<br> Conclusion: T<sub>1</sub>-FLAIR-BLADE may be superior to T<sub>1</sub>-SE in demonstrating brain structures in children who cannot stay still and may be used to supplement or replace T<sub>1</sub>-SE when T<sub>1</sub>-SE is insufficient for patient motion.<br>


  • Magnetic resonance in medical sciences : MRMS

    Magnetic resonance in medical sciences : MRMS 11(1), 17-26, 2012-03-01

    Japanese Society for Magnetic Resonance in Medicine

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