Visualization of Endolymphatic Hydrops in Meniere's Disease after Single-dose Intravenous Gadolinium-based Contrast Medium : Timing of Optimal Enhancement

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著者

    • NAGANAWA Shinji
    • Department of Radiology, Nagoya University Graduate School of Medicine
    • KAWAI Hisashi
    • Department of Radiology, Nagoya University Graduate School of Medicine
    • BOKURA Kiminori
    • Department of Radiology, Nagoya University Graduate School of Medicine
    • SONE Michihiko
    • Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine
    • NAKASHIMA Tsutomu
    • Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine

抄録

Purpose: Visualization of endolymphatic hydrops (EH) in patients with Ménière's disease (MD) is now possible by heavily T<sub>2</sub>-weighted 3-dimensional fluid-attenuated inversion recovery (hT<sub>2</sub>W-3D-FLAIR) obtained 4 hours after intravenous (IV) administration of single dose gadolinium-based contrast medium (GBCM). Although maximum enhancement has been reported 4 hours after contrast administration in healthy volunteers, the timing of optimal enhancement in patients with MD is not reported. We investigated if that optimal timing is earlier or later than 4 hours.<br> Materials and Methods: We evaluated 10 consecutive patients with suspected MD whom we randomly divided into 2 groups. We obtained hT<sub>2</sub>W-3D-FLAIR before GBCM administration and 10 min, 3.5 hours, and 4 hours after GBCM administration in Group A and before and 10 min, 4 hours, and 4.5 hours after GBCM administration in Group B. We compared signal intensity ratio (SIR) values of the perilymph and pons between 3.5 and 4 hours in Group A and between 4 and 4.5 hours in Group B and evaluated grades of EH at 3.5 and 4 hours in Group A and at 4 and 4.5 hours in Group B.<br> Results: SIR values did not differ significantly between 3.5 and 4 hours in Group A and between 4 and 4.5 hours in Group B. However, SIR values at 4 hours were significantly higher in Group A than Group B. Grades of EH agreed between 3.5 and 4 hours in Group A and between 4 and 4.5 hours in Group B.<br> Conclusion: The optimal timing of contrast enhancement in patients with suspected MD remains unclear, but evaluation of EH may be possible from 3.5 to 4.5 hours after contrast administration.<br>

収録刊行物

  • Magnetic resonance in medical sciences : MRMS

    Magnetic resonance in medical sciences : MRMS 11(1), 43-51, 2012-03-01

    日本磁気共鳴医学会

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各種コード

  • NII論文ID(NAID)
    10030284811
  • NII書誌ID(NCID)
    AA11648770
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13473182
  • データ提供元
    CJP書誌  J-STAGE 
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