Effect of low level fluoride on demineralization kinetics of human dental enamel

DOI 参考文献14件
  • Nakano Takashi
    Department of Pediatric Dentistry, School of Dentistry, Aichi-Gakuin University
  • Neale Celia
    Division of Oral Biology, School of Dentistry, Leeds University
  • Robinson Colin
    Division of Oral Biology, School of Dentistry, Leeds University
  • Sakakibara Shoichi
    Department of Pediatric Dentistry, School of Dentistry, Aichi-Gakuin University
  • Komoto Shintaro
    Department of Pediatric Dentistry, School of Dentistry, Aichi-Gakuin University
  • Nakagaki Haruo
    Department of Preventive Dentistry and Dental Public Health, School of Dentistry, Aichi-Gakuin University
  • Fukuta Osamu
    Department of Pediatric Dentistry, School of Dentistry, Aichi-Gakuin University

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The purpose of this study was to examine the effect of fluoride levels similar to those reported for saliva from low fluoridated and high fluoridated water areas on the demineralization of human permanent enamel. An adaptation of the method described by Robinson et al. was used. Sections of sound enamel were immersed in a vial containing demineralizing solution [2.0 mM Ca(NO3)2, 1.2 mM KHPO4 in 50 mM acetic acid, pH 4.8] for 1 hour. The demineralizing solution contained 0, 0.02 or 0.05 ppm fluoride, added as NaF was prepared. Twenty microliters aliquots were taken from the demineralizing solution at the time point up to 1 hour, with a sampling frequency bias towards the early time point. The phosphate content of the removed sample was determined by colorimetry. When the mineral loss curves for fluoridated and non-fluoridated demineralizing solutions were compared, there were significant differences between both groups. There was a decrease in the net mineral loss when fluoride was used. This result suggested that salivary fluoride levels of 0.02 ppm and 0.05 ppm had a protective effect against demineralization.

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