Translesion DNA Synthesis and Hsp90
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- Yamashita Takayuki
- Laboratory of Molecular Genetics, The Institute for Molecular and Cellular Regulation, Gunma University
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- Oda Tsukasa
- Laboratory of Molecular Genetics, The Institute for Molecular and Cellular Regulation, Gunma University
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- Sekimoto Takayuki
- Laboratory of Molecular Genetics, The Institute for Molecular and Cellular Regulation, Gunma University
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Abstract
Translesion DNA synthesis (TLS) is an essential mechanism for DNA damage tolerance during genome duplication by bypassing DNA lesions with use of specialized low-fidelity polymerases. Thus, TLS is inherently mutagenic, which is presumed to be involved in cancer initiation and progression. Increasing attention has focused on post-translational regulatory mechanisms of TLS polymerases, including covalent modification (e.g., phosphorylation) and proteasomal degradation. In this review article, we focus on our findings on Hsp90-mediated regulation of TLS polymerases and discuss potential pharmacological effects of Hsp90 inhibitors in cancer therapy.<br>
Journal
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- Genes and Environment
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Genes and Environment 34 (2), 89-93, 2012
The Japanese Environmental Mutagen Society
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Details 詳細情報について
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- CRID
- 1390001205256658048
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- NII Article ID
- 10030311653
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- NII Book ID
- AA1212552X
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- COI
- 1:CAS:528:DC%2BC38XhtVGgsrbO
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- ISSN
- 18807062
- 18807046
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- NDL BIB ID
- 023634514
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed