Diagnostic imaging of higher brain dysfunction in patients with adult moyamoya disease using statistical imaging analysis for [123I]iomazenil single photon emission computed tomography

• NAKAGAWARA Jyoji

  Departments of Neurosurgery and Stroke Center, Nakamura Memorial Hospital

• OSATO Toshiaki

  Departments of Neurosurgery and Stroke Center, Nakamura Memorial Hospital

• KAMIYAMA Kenji

  Departments of Neurosurgery and Stroke Center, Nakamura Memorial Hospital

• HONJO Kaori

  Departments of Neurosurgery and Stroke Center, Nakamura Memorial Hospital

• SUGIO Hironori

  Departments of Neurosurgery and Stroke Center, Nakamura Memorial Hospital

• FUMOTO Kentarou

  Departments of Neurosurgery and Stroke Center, Nakamura Memorial Hospital

• MURAHASHI Takeo

  Departments of Neurosurgery and Stroke Center, Nakamura Memorial Hospital

• TAKADA Hidekazu

  Departments of Neurosurgery and Stroke Center, Nakamura Memorial Hospital

• WATANABE Toshiichi

  Departments of Neurosurgery and Stroke Center, Nakamura Memorial Hospital

• NAKAMURA Hirohiko

  Departments of Neurosurgery and Stroke Center, Nakamura Memorial Hospital

書誌事項

タイトル別名

• Diagnostic Imaging of Higher Brain Dysfunction in Patients With Adult Moyamoya Disease Using Statistical Imaging Analysis for [¹²³I]Iomazenil Single Photon Emission Computed Tomography

抄録

[¹²³I]iomazenil (IMZ) is a specific radioligand for the central benzodiazepine (BZ) receptor that may be useful as a marker of cortical neuron loss after cerebral ischemia using single photon emission computed tomography (SPECT). This study used statistical imaging analysis for IMZ-SPECT to investigate the relationship between higher brain dysfunction and cortical neuron loss in the medial frontal lobes, to establish a confirmatory diagnosis of higher brain dysfunction in patients with adult moyamoya disease. IMZ-SPECT was estimated by three-dimensional stereotactic surface projections (3D-SSP). Cortical neuron loss was analyzed using the stereotactic extraction estimation (SEE) method (level 3: gyrus level) for 3D-SSP Z-score maps (Z-score >2). Extent of pixels with significant reduction of BZ receptor density within the target gyri (i.e. bilateral medial frontal gyri [MFGs] and anterior cingulate gyri [ACGs]) was calculated. In 6 patients with higher brain dysfunction, significant cortical neuron loss was observed in the bilateral MFGs in 4 patients, unilateral MFG in 1 patient, and bilateral ACGs in 2 patients. In 12 patients without higher brain dysfunction, no significant cortical neuron loss was observed in the bilateral MFGs or ACGs, and mild loss was observed in the bilateral MFGs in 2 patients, unilateral MFG in 4 patients, and unilateral ACG in 2 patients. Long-standing mild hemodynamic ischemia in the anterior circulation of patients with adult moyamoya disease could lead to incomplete brain infarction within the medial frontal lobes. Statistical imaging analysis using 3D-SSP and SEE methods for IMZ-SPECT could demonstrate significant cortical neuron loss in the bilateral frontal medial cortices involving MFG and/or ACG which correlate with higher brain dysfunction in patients with adult moyamoya disease.<br>

収録刊行物

• Neurologia medico-chirurgica

  Neurologia medico-chirurgica 52 (5), 318-326, 2012

  一般社団法人 日本脳神経外科学会

キーワード

• higher brain dysfunction
• moyamoya disease
• three-dimensional stereotactic surface projections
• iodine-123-iomazenil
• single photon emission computed tomography

詳細情報

• CRID: 1390282680033429248
• NII論文ID: 10030314541
• NII書誌ID: AN00358613
• DOI: 10.2176/nmc.52.318
• COI: 1:STN:280:DC%2BC38jgvVSisA%3D%3D
• ISSN: 13498029
• ISSN: 04708105
• PubMed: 22688069
• Web Site: https://www.jstage.jst.go.jp/article/nmc/52/5/52_2012-0015/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013156058
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可