Does a combination pill of antihypertensive drugs improve medication adherence in Japanese? A randomized controlled trial

• Matsumura Kiyoshi

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Arima Hisatomi

  The George Institute for Global Health, University of Sydney The George Institute for Global Health, University of Sydney

• Tominaga Mitsuhiro

  Division of Cardiology, Kyushu Central Hospital Division of Cardiology, Kyushu Central Hospital

• Ohtsubo Toshio

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Sasaguri Toshiyuki

  Department of Clinical Pharmacology, Kyushu University Department of Clinical Pharmacology, Kyushu University

• Fujii Koji

  Division of Internal Medicine, Imazu Red Cross Hospital Division of Internal Medicine, Imazu Red Cross Hospital

• Fukuhara Masayo

  Department of Environmental Medicine, Kyushu University Department of Environmental Medicine, Kyushu University

• Uezono Keiko

  Institute of Health Science, Kyushu University Institute of Health Science, Kyushu University

• Morinaga Yuki

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Ohta Yuko

  Division of Hypertension, National Kyushu Medical Center Division of Hypertension, National Kyushu Medical Center

• Otonari Takatoshi

  Otonari Clinic Otonari Clinic

• Kawasaki Junya

  Kawasaki Cardiovascular Clinic Kawasaki Cardiovascular Clinic

• Kato Isao

  Kato Clinic Kato Clinic

• Tsuchihashi Takuya

  Division of Hypertension, National Kyushu Medical Center Division of Hypertension, National Kyushu Medical Center

• Muratani Hiromi

• Kagiyama Shuntaro

• Nagao Tetsuhiko

• Fujishima Yae

• Arakawa Kimika

• Fukudome Yuji

• Onaka Uran

• Goto Kenichi

• Nakamura Yoshito

• Yamada Junpei

• Sugi Kenichi

• Arase Koichi

• Kawadoko Toshiharu

• Nakamura Shin

• Midorikawa Keiichi

• Nomiyama Kensuke

• Hashimoto Toshihiko

• Murakami Atsushi

• Fukuda Koichi

• Soh Toshimitsu

• Eshita Akihiko

• Ishibashi Morioki

書誌事項

タイトル別名

• Does a Combination Pill of Antihypertensive Drugs Improve Medication Adherence in Japanese?
• – A Randomized Controlled Trial –

抄録

Background: In order to achieve target blood pressure levels to prevent cardiovascular disease, combination therapy of antihypertensive drugs is often required, although it is thought that requiring a patient to take many different pills would reduce adherence to the medication regimen. Whether antihypertensive treatment with a single pill combining antihypertensive drugs would improve medication adherence and blood pressure control was investigated. Methods and Results: A total of 207 hypertensive subjects were randomly assigned to a combination pill group (losartan 50mg/hydrochlorothiazide 12.5mg; n=103) or a control group (an angiotensin receptor blocker and a thiazide diuretic; n=104). Medication adherence was evaluated by pill counts at 1, 3, and 6 months after randomization. The mean adherence rates over 6 months were not different between the 2 groups: 98% in the combination pill group and 98% in the control group. Moreover, the 2 groups included similar numbers of subjects with relatively poor adherence rates (<90%) in each treatment period. The mean blood pressures over the 6-month treatment period were not different between the groups: 131/75mmHg in the combination pill group and 130/75mmHg in the control group (P=0.84/0.96). Conclusions: There were no appreciable effects of the combination pill of antihypertensive drugs on medication adherence or blood pressure control in Japanese patients over a 6-month period. (Circ J 2012; 76: 1415-1422)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 76 (6), 1415-1422, 2012

  一般社団法人 日本循環器学会

キーワード

• Adherence
• Combination pill
• Hypertension
• Randomized controlled trial

詳細情報

• CRID: 1390001205104064640
• NII論文ID: 10030316225
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-11-1481
• COI: 1:CAS:528:DC%2BC38Xpsl2kurw%3D
• ISSN: 13474820
• ISSN: 13469843
• ISSN: http://id.crossref.org/issn/13469843
• PubMed: 22447014
• Web Site: https://www.jstage.jst.go.jp/article/circj/76/6/76_CJ-11-1481/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013173566
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可