Disrupted Regulation of Ghrelin Production Under Antihypertensive Treatment in Spontaneously Hypertensive Rats
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- Hamada Naokazu
- Department of Digestive and Life-Style Related Disease, Health Research Course, Human and Environmental Sciences, Kagoshima University Graduate School of Medicine and Dental Sciences
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- Nishi Yoshihiro
- Department of Physiology, Kurume University School of Medicine
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- Tajiri Yuji
- Division of Endocrinology and Metabolism, Kurume University School of Medicine
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- Setoyama Kentaro
- Frontier Science Research Center, Kagoshima University
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- Kamimura Ryozo
- Frontier Science Research Center, Kagoshima University
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- Miyahara Kenkichi
- Division of Cardiology, Shinkyo Hospital
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- Nuruki Norihito
- Department of Digestive and Life-Style Related Disease, Health Research Course, Human and Environmental Sciences, Kagoshima University Graduate School of Medicine and Dental Sciences
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- Hosoda Hiroshi
- Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute
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- Kangawa Kenji
- Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute
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- Kojima Masayasu
- Institute of Life Science, Kurume University
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- Mifune Hiroharu
- Institute of Animal Experimentation, Kurume University School of Medicine
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Abstract
Background: Ghrelin is an acylated peptide hormone mainly secreted from the stomach. When administrated externally it modulates vascular tone mainly through the regulation of autonomic nerve activity. However, the effects of blood pressure (BP) on the production and secretion of ghrelin remain to be clarified. Methods and Results: We examined the stomach and plasma levels of ghrelin in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats after a 4-week-intervention with antihypertensive agents (candesartan-cilexetil [ARB], doxazosin [DZN], metoprolol [MP], reserpine [RES]) to clarify the influence of BP on the secretion of ghrelin. The effect of these agents on ghrelin production and secretion were examined by comparing vehicle-treated controls (WKY-Intact, SHR-Intact). Treatment with the 4 antihypertensive drugs all yielded a significant decline in systolic BP in both SHR and WKY. Under these conditions, significantly lower levels of stomach and plasma ghrelin were detected in WKY treated with ARB (P<0.05), DZN (P<0.05), MP (P<0.05) and RES (P<0.05) compared with WKY-Intact, whereas no significant change in the ghrelin levels in the stomach and plasma were detected in SHR under the same treatments. Conclusions: The findings imply that the production and secretion of ghrelin are controlled by the ambient vascular tone and vice versa in normotensive WKY. This inter-relationship between ghrelin and BP seems to be disrupted in SHR. (Circ J 2012; 76: 1423-1429)<br>
Journal
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- Circulation Journal
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Circulation Journal 76 (6), 1423-1429, 2012
The Japanese Circulation Society
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Details 詳細情報について
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- CRID
- 1390001205104135808
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- NII Article ID
- 10030316253
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- NII Book ID
- AA11591968
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- COI
- 1:CAS:528:DC%2BC38Xpsl2kurs%3D
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- ISSN
- 13474820
- 13469843
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- PubMed
- 22447011
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed