Aspirin Reduces Cerebrovascular Events in Type 2 Diabetic Patients With Poorly Controlled Blood Pressure

• Soejima Hirofumi

  Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University Health Care Center, Kumamoto University Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University Health Care Center, Kumamoto University

• Ogawa Hisao

  Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Morimoto Takeshi

  Center for Medical Education, Kyoto University Graduate School of Medicine Center for Medical Education, Kyoto University Graduate School of Medicine

• Nakayama Masafumi

  Nakayama Cardiovascular Clinic Nakayama Cardiovascular Clinic

• Okada Sadanori

  First Department of Internal Medicine, Nara Medical University First Department of Internal Medicine, Nara Medical University

• Uemura Shiro

  First Department of Internal Medicine, Nara Medical University First Department of Internal Medicine, Nara Medical University

• Kanauchi Masao

  Department of Health and Nutrition, Faculty of Health Science, Kio University Department of Health and Nutrition, Faculty of Health Science, Kio University

• Doi Naofumi

  First Department of Internal Medicine, Nara Medical University First Department of Internal Medicine, Nara Medical University

• Sakuma Mio

  Center for Medical Education, Kyoto University Graduate School of Medicine Center for Medical Education, Kyoto University Graduate School of Medicine

• Jinnouchi Hideaki

  Jinnouchi Clinic, Diabetes Care Center Jinnouchi Clinic, Diabetes Care Center

• Sugiyama Seigo

  Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Waki Masako

  Division of Endocrinology and Metabolism, Department of Internal Medicine, Shizuoka City Shizuoka Hospital Division of Endocrinology and Metabolism, Department of Internal Medicine, Shizuoka City Shizuoka Hospital

• Saito Yoshihiko

  First Department of Internal Medicine, Nara Medical University Department of Regulatory Medicine of Blood Pressure, Nara Medical University First Department of Internal Medicine, Nara Medical University Department of Regulatory Medicine of Blood Pressure, Nara Medical University

書誌事項

タイトル別名

• – Subanalysis From the JPAD Trial –

抄録

Background: There are few data that demonstrate a significant effect of aspirin therapy for diabetic patients. To clarify the effect of the primary prevention of aspirin therapy in diabetic patients, the relationship between blood pressure (BP) and the incidence of atherosclerotic events was investigated in participants in the Japanese primary prevention of atherosclerosis with aspirin for diabetes (JPAD) trial. Methods and Results: We divided the JPAD participants according to their systolic (SBP) and diastolic (DBP) BPs at enrollment (SBP ≥140mmHg and/or DBP ≥90mmHg: unattained group, SBP <140mmHg and DBP <90mmHg: attained group). The incidence of the primary atherosclerotic events, especially cerebrovascular events, was higher in the unattained group than in the attained group. The incidence of cerebrovascular events was higher in the unattained group than in the attained group in patients without aspirin therapy; however, the incidence of cerebrovascular events in the unattained group was as low as the incidence in the attained group in patients undergoing aspirin therapy. Cox proportional hazards analysis revealed that BP level was an independent predictor for cerebrovascular events in diabetic patients. Conclusions: Aspirin therapy may reduce cerebrovascular events in diabetic patients with higher BP. Aspirin therapy could be an additional strategy as primary prevention for diabetic patients with higher BP. (Circ J 2012; 76: 1526-1532)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 76 (6), 1526-1532, 2012

  一般社団法人 日本循環器学会

キーワード

• Blood pressure
• Cardiovascular diseases
• Diabetes mellitus
• Hypertension
• Stroke

詳細情報

• CRID: 1390001205104107008
• NII論文ID: 10030316698
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-11-1033
• COI: 1:CAS:528:DC%2BC38Xpsl2rsrs%3D
• ISSN: 13474820
• ISSN: 13469843
• PubMed: 22447019
• Web Site: https://www.jstage.jst.go.jp/article/circj/76/6/76_CJ-11-1033/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013173580
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可