モリンガ葉のスギ花粉アレルゲン誘発好酸球集積に対する抑制作用  [in Japanese] Inhibitory Effect of Moringa Leaf on Cedar Pollen-induced Eosinophil Accumulation in Mice  [in Japanese]

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Abstract

5週齢のBALB/c系雌マウスにスギ花粉アレルゲンを5回感作した後,腹腔内にアレルゲンを投与して好酸球を集積させるI型アレルギーの遅発相モデルを作製した.このモデルに対して,モリンガ(<I>Moringa oleifera</I>)の葉を3種の混合比(0.3%,1.0%および3.0%)で混じた粉末飼料を自由摂取させ,好酸球の集積および血清中の総IgE量に対する影響を調べた.通常の飼料を与えた対照群と比較してモリンガ葉を0.3%および3.0%与えた群は,総白血球数および好酸球数で有意な低値を示した.血清中総IgE量では対照群と比較して3.0%のモリンガ葉を与えた群が有意な低値を示した.以上の結果より,モリンガ葉は経口的に摂取することでI型アレルギーに対して抑制作用を有する可能性が示された.

We established an allergic model of the late phase of type I hypersensitivity reaction to cedar pollen in mice. In this model, BALB/c mice (5-week-old females) were immunized five times with cedar pollen allergen, and eosinophil accumulation in the peritoneal cavity was elicited by an intraperitoneal injection of the allergen. We investigated the effects of the leaf of <I>Moringa oleifera </I>on allergen-induced eosinophil accumulation and total IgE in serum by giving freely feeding mice a powder diet containing 0.3%, 1.0%, and 3.0% <I>M. odeifera </I>leaf powder. Compared to the control group (normal diet), the number of total leukocytes and eosinophils accumulated in the peritoneal cavity was significantly reduced in the groups given the diet containing 0.3% and 3.0% <I>M. oleifera </I>leaf powder. However, there were no differences in the number of lymphocytes, monocytes, and neutrophils between all groups. Furthermore, the serum level of total IgE was reduced in the <I>M. oleifera </I>leaf powder-treated groups. These results provide laboratory evidence that <I>M. oleifera </I>leaf powder reduces eosinophil accumulation at the site of allergic inflammation and attenuates the development of IgE-mediated allergy.

Journal

  • Nippon Shokuhin Kagaku Kogaku Kaishi

    Nippon Shokuhin Kagaku Kogaku Kaishi 58(12), 604-607, 2011-12-15

    Japanese Society for Food Science and Technology

References:  18

Codes

  • NII Article ID (NAID)
    10030333557
  • NII NACSIS-CAT ID (NCID)
    AN10467499
  • Text Lang
    JPN
  • Article Type
    NOT
  • ISSN
    1341027X
  • NDL Article ID
    023336558
  • NDL Call No.
    Z17-126
  • Data Source
    CJP  NDL  IR  J-STAGE 
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