Coffee and Caffeine Improve Insulin Sensitivity and Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet

• MATSUDA Yuji

  Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University

• KOBAYASHI Misato

  Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University

• YAMAUCHI Rie

  Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University

• OJIKA Makoto

  Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University

• HIRAMITSU Masanori

  Product Research and Development Department, Pokka Corporation

• INOUE Takashi

  Product Research and Development Department, Pokka Corporation

• KATAGIRI Takao

  Product Research and Development Department, Pokka Corporation

• MURAI Atsushi

  Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University

• HORIO Fumihiko

  Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University

Abstract

We have previously demonstrated that coffee and caffeine ameliorated hyperglycemia in spontaneously diabetic KK-A^y mice. This present study evaluates the antidiabetic effects of coffee and caffeine on high-fat-diet-induced impaired glucose tolerance in C57BL/6J mice. C57BL/6J mice fed a high-fat diet were given regular drinking water (control group), or a 2.5-fold-diluted coffee or caffeine solution (200 mg/L) for 17 weeks. The ingestion of coffee or caffeine improved glucose tolerance, insulin sensitivity, and hyperinsulinemia when compared with mice in the control group. The adipose tissue mRNA levels of inflammatory adipocytokines (MCP-1 and IL-6) and the liver mRNA levels of genes related to fatty acid synthesis were lower in the coffee and caffeine groups than those in the control group. These results suggest that coffee and caffeine exerted an ameliorative effect on high-fat-diet-induced impaired glucose tolerance by improving insulin sensitivity. This effect might be attributable in part to the reduction of inflammatory adipocytokine expression.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 75 (12), 2309-2315, 2011

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• coffee
• caffeine
• diet-induced impaired glucose tolerance
• antidiabetic effect
• insulin resistance

Details

• CRID: 1390282681457267200
• NII Article ID: 10030397482
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.110452
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 023359833
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023359833
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.110452
• Web Site: https://search.jamas.or.jp/link/ui/2012140746
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed