Regulation of Lipid Metabolism by Palmitoleate and Eicosapentaenoic Acid (EPA) in Mice Fed a High-Fat Diet

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  • SHIBA Sachiko
    Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University
  • TSUNODA Nobuyo
    Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University
  • WAKUTSU Masaki
    Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University
  • MURAKI Etsuko
    Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University
  • SONODA Mariko
    Department of Food and Nutritional Science, Graduate School of Humanities and Sciences, Ochanomizu University
  • TAM Phyllis S. Y.
    Department of Food and Nutritional Science, Graduate School of Humanities and Sciences, Ochanomizu University
  • FUJIWARA Yoko
    Department of Food and Nutritional Science, Graduate School of Humanities and Sciences, Ochanomizu University
  • IKEMOTO Shinji
    Department of Food and Nutritional Science, Graduate School of Humanities and Sciences, Ochanomizu University
  • KASONO Keizo
    Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University

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Abstract

We investigated whether oral administration of palmitoleate ameliorates disorders of lipid metabolism to clarify the effects of one of the components of fish oil. Lipid levels in the liver and plasma were significantly decreased by palmitoleate and by EPA administration. These results suggest that palmitoleate, in addition to EPA, plays a role in the regulation of lipid metabolism by fish oil.

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