Sensing of Sulfhydryl Compounds with Thermoresponsive Gold Nanocomposites

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  • 熱応答性金ナノ複合体を用いるチオール化合物のセンシング
  • ネツ オウトウセイキン ナノ フクゴウタイ オ モチイル チオール カゴウブツ ノ センシング

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Abstract

Sensing of sulfhydryl compounds with thermoresponsive gold nanocomposites was reviewed based on research conducted by the present author. The combination of thermoresponsive polymers and gold nanoparticles enabled us to develop not only their inherent functions, but also new functions that would produce novel analytical systems. Aggregated gold nanoparticles in thermoresponsive gold nanocomposites became disassembled by thermal stimuli ; heating followed by cooling, resulting in a change in the solution color from blue-purple to red. Several colorimetric assay systems were fabricated by using gold nanocomposites based on the facts that cysteine prohibited disassembly of the gold nanocomposites while glutathione facilitated the disassembly. The replacement of the other thermoresponsive polymer conjugated with gold nanoparticles allowed us to develop another colorimetric system of the sulfhydryl amino acid, such as homocysteine, with high selectivity. In addition to the sensing systems, spontaneous growth of small gold nanoparticles (ca. 2 nm) conjugated with thermoresponsive polymer was also discussed from the viewpoint of a phase transition induced by heating a solution. Sulfhydryl compounds inhibited growth of the gold nanocomposites, resulting in a suppression of the development of reddish color.

Journal

  • BUNSEKI KAGAKU

    BUNSEKI KAGAKU 61 (6), 535-545, 2012

    The Japan Society for Analytical Chemistry

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