Effects of Hesperidin on the Progression of Hypercholesterolemia and Fatty Liver Induced by High-Cholesterol Diet in Rats

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Author(s)

    • Wang Xinhui WANG Xinhui
    • Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University
    • WANG Zhongzhi
    • Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University
    • MATSUDA Akiko
    • Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University
    • SHINODA Waka
    • Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University
    • MIURA Norimasa
    • Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University
    • KIMURA Koji
    • Division of Functional Radiation Science, Research Center for Bioscience and Technology, Tottori University

Abstract

The protective effects of hesperidin against hypercholesterolemia and fatty liver were examined in male Wistar rats fed a high-cholesterol diet for 12 weeks. Compared with a standard diet, a high-cholesterol diet not only increased body weights, liver weights, and serum concentration of cholesterol, but also induced the fatty degeneration (steatosis) of liver. Hesperidin (0.08%) reduced levels of hepatic steatosis, adipose tissue and liver weights (<I>P</I> < 0.05), serum total cholesterol and retinol binding protein (RBP) 4 concentrations (<I>P</I> < 0.05) in rats fed with high-cholesterol diet, while reduction in low-density lipoprotein cholesterol levels and triglyceride concentrations was not significant. It also attenuated the marked changes in mRNA expression of lipid metabolism–related proteins: RBP, heart fatty acid–binding protein (H-FABP), and cutaneous fatty acid–binding protein (C-FABP), in liver and adipose tissue. According to the results of gas chromatography, serum concentrations of total cholesterol and biomarkers of cholesterol synthesis (lathosterol) and absorption (campesterol, <I>β</I>-sitosterol) were lower, and concentrations of cholesterol in feces were higher in the rats given hesperidin (<I>P</I> < 0.05). Hesperidin may improve hypercholesterolemia and fatty liver by inhibiting both the synthesis and absorption of cholesterol and regulating the expression of mRNA for RBP, C-FABP, and H-FABP.

Journal

  • Journal of Pharmacological Sciences

    Journal of Pharmacological Sciences 117(3), 129-138, 2011-11-20

    The Japanese Pharmacological Society

References:  64

Codes

  • NII Article ID (NAID)
    10030453113
  • NII NACSIS-CAT ID (NCID)
    AA11806667
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    13478613
  • NDL Article ID
    023319956
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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