Bismuth protects against arsenite-induced inhibition of proteoglycan synthesis in cultured vascular endothelial cells
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- Fujiwara Yasuyuki
- Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
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- Yamamoto Chika
- Department of Environmental Health, Faculty of Pharmaceutical Sciences, Hokuriku University
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- Inagaki Takayuki
- Department of Environmental Health, Faculty of Pharmaceutical Sciences, Hokuriku University
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- Satoh Masahiko
- Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
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- Kaji Toshiyuki
- Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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抄録
Chronic ingestion of arsenic is associated with an increased risk of vascular disease such as atherosclerosis. Previously, we showed that arsenite inhibits the synthesis of general proteoglycans (PGs), which are key molecules in the progression of atherosclerosis, in vascular endothelial cells. In the present study, we investigated the effect of several metals on arsenite-induced inhibitory effect in endothelial cells. The results indicate that, after 24-hr incubation, the inhibition of PG synthesis caused by sodium arsenite was protected by bismuth nitrate but not zinc sulfate, manganese chloride, nickel chloride or cobalt chloride. The accumulation of arsenic in the cell layer was significantly decreased by bismuth after 12-hr incubation and that of bismuth was also decreased by arsenite. It was therefore suggested that the protective effect of bismuth against the inhibitory effect of arsenite on PG synthesis in vascular endothelial cells may be due, at least in part, to the decrease in cellular arsenic accumulation.
収録刊行物
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 37 (4), 837-843, 2012
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390282679883225344
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- NII論文ID
- 10030502600
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- NII書誌ID
- AN00002808
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- COI
- 1:STN:280:DC%2BC38flsFartg%3D%3D
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- ISSN
- 18803989
- 03881350
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- NDL書誌ID
- 023926290
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- PubMed
- 22863863
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可