Synthesis of Triazole-linked Analogues of RNA (TLRNA)

• Fujino Tomoko

  Department of Chemistry, Tohoku University

• Endo Kenta

  Department of Chemistry, Tohoku University

• Yamazaki Naomi

  Department of Chemistry, Tohoku University

• Isobe Hiroyuki

  Department of Chemistry, Tohoku University

書誌事項

タイトル別名

• Synthesis of Triazole-linked Analogues of RNA (^TLRNA)

抄録

A triazole-linked analogue of RNA (^TLRNA) has been developed. Monomeric ribonucleoside analogues bearing natural nucleobases were prepared from D-xylose to afford the elongating units in gram quantities. The puckering of the monomeric analogues was similar to that of natural ribonucleosides and preferred the North-type conformation. An efficient elongation reaction via the copper-catalyzed Huisgen cycloaddition on a solid support was used for the synthesis of trinucleotides.

収録刊行物

• Chemistry Letters

  Chemistry Letters 41 (4), 403-405, 2012

  公益社団法人 日本化学会

キーワード

• General Chemistry

詳細情報

• CRID: 1390001204588738944
• NII論文ID: 10030544765
• NII書誌ID: AA00603318
• DOI: 10.1246/cl.2012.403
• COI: 1:CAS:528:DC%2BC38XmsVakurc%3D
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/41/4/403/55640854/cl.2012.403.pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可