Impulsive Behavior and Nicotinic Acetylcholine Receptors

DOI Web Site PubMed 被引用文献4件 参考文献186件
  • Ohmura Yu
    Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Japan
  • Tsutsui-Kimura Iku
    Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Japan
  • Yoshioka Mitsuhiro
    Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Japan

この論文をさがす

抄録

Higher impulsivity is thought to be a risk factor for drug addiction, criminal involvement, and suicide. Excessive levels of impulsivity are often observed in several psychiatric disorders including attention-deficit/hyperactivity disorder and schizophrenia. Previous studies have demonstrated that nicotinic acetylcholine receptors (nAChRs) are involved in impulsive behavior. Here, we introduce recent advances in this field and describe the role of the following nAChR-related brain mechanisms in modulating impulsive behavior: dopamine release in the ventral striatum; α4β2 nAChRs in the infralimbic cortex, which is a ventral part of the medial prefrontal cortex (mPFC); and dopamine release in the mPFC. We also suggest several potential therapeutic drugs to address these mechanisms in impulsivity-related disorders and explore future directions to further elucidate the roles of central nAChRs in impulsive behavior.

収録刊行物

被引用文献 (4)*注記

もっと見る

参考文献 (186)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ