Impulsive Behavior and Nicotinic Acetylcholine Receptors

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Author(s)

Abstract

Higher impulsivity is thought to be a risk factor for drug addiction, criminal involvement, and suicide. Excessive levels of impulsivity are often observed in several psychiatric disorders including attention-deficit/hyperactivity disorder and schizophrenia. Previous studies have demonstrated that nicotinic acetylcholine receptors (nAChRs) are involved in impulsive behavior. Here, we introduce recent advances in this field and describe the role of the following nAChR-related brain mechanisms in modulating impulsive behavior: dopamine release in the ventral striatum; <I>α</I>4<I>β</I>2 nAChRs in the infralimbic cortex, which is a ventral part of the medial prefrontal cortex (mPFC); and dopamine release in the mPFC. We also suggest several potential therapeutic drugs to address these mechanisms in impulsivity-related disorders and explore future directions to further elucidate the roles of central nAChRs in impulsive behavior.

Journal

  • Journal of Pharmacological Sciences

    Journal of Pharmacological Sciences 118(4), 413-422, 2012-04-20

    The Japanese Pharmacological Society

References:  100

Codes

  • NII Article ID (NAID)
    10030571764
  • NII NACSIS-CAT ID (NCID)
    AA11806667
  • Text Lang
    ENG
  • Article Type
    REV
  • ISSN
    13478613
  • NDL Article ID
    023590530
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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