Alternative lengthening of telomeres pathway : Recombination-mediated telomere maintenance mechanism in human cells

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Unlimitedly proliferating cells need to acquire the telomere DNA maintenance mechanism, to counteract possible shortening through multiple rounds of replication and segregation of linear chromosomes. Most human cancer cells express telomerase whereas the other cells utilize the alternative lengthening of telomeres (ALT) pathway to elongate telomere DNA. It is suggested that ALT depends on the recombination between telomere repetitive DNAs. However, the molecular details remain unknown. Recent studies have provided evidence of special structures of telomere DNA and genes essential for the phenotypes of ALT cells. The molecular models of the ALT pathway should be validated to elucidate recombination-mediated telomere maintenance and promote the applications to anti-cancer therapy.

収録刊行物

  • The journal of biochemistry

    The journal of biochemistry 149(1), 5-14, 2011-01-01

    Japanese Biochemical Society

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各種コード

  • NII論文ID(NAID)
    10030582554
  • NII書誌ID(NCID)
    AA00694073
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    0021924X
  • NDL 記事登録ID
    10963770
  • NDL 雑誌分類
    ZR2(科学技術--生物学--生化学)
  • NDL 請求記号
    Z53-B472
  • データ提供元
    CJP書誌  NDL  IR 
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