Cancer early dissemination : cancerous epithelial-mesenchymal transdifferentiation and transforming growth factor β signalling

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Contrary to the long believed hypothesis, it is now evident that breast cancer cells can disseminate from the early phases of the oncogenesis; and that such early disseminated cells sometimes survive at the sites of dissemination and may outgrow after a long latency of years and decades. For cancer cells to leave their origin, they must at least transiently loosen their adhesion with adjacent epithelial cells and stroma, and become motile while avoiding anoikis. Such processes resemble epithelial-mesenchymal transdifferentiation (EMT), which normally takes place in situations such as embryogenesis and wound healing. Interestingly, the occurrence of an EMT-like process in breast cancer cells has been implicated in the generation of cancer stem-like cells, in which TGFβ1 signaling often plays core roles. Here, I discuss the current knowledge regarding cancerous EMT and its signaling pathways with the aim to consider the possible mechanisms of early dissemination, and also the generation of cancer stem-like cells in mammary tumor.

収録刊行物

  • The journal of biochemistry

    The journal of biochemistry 149(6), 633-639, 2011-06-01

    Japanese Biochemical Society

参考文献:  65件中 1-65件 を表示

被引用文献:  5件中 1-5件 を表示

各種コード

  • NII論文ID(NAID)
    10030585535
  • NII書誌ID(NCID)
    AA00694073
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    0021924X
  • NDL 記事登録ID
    11100396
  • NDL 雑誌分類
    ZR2(科学技術--生物学--生化学)
  • NDL 請求記号
    Z53-B472
  • データ提供元
    CJP書誌  CJP引用  NDL  IR 
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