Genetic dissection of Nucleoporin 160 (Nup160), a gene involved in multiple phenotypes of reproductive isolation in Drosophila

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Abstract

Previous reports have suggested that the <i>Nucleoporin 160</i> (<i>Nup160</i>) gene of <i>Drosophila simulans</i> (<i>Nup160<sup>sim</sup></i>) causes the hybrid inviability, female sterility, and morphological anomalies that are observed in crosses with <i>D. melanogaster</i>. Here we have confirmed this observation by transposon excision from the <i>P{EP}Nup160<sup>EP372</sup></i> insertion mutation of <i>D. melanogaster</i>. Null mutations of the <i>Nup160</i> gene resulted in the three phenotypes caused by <i>Nup160<sup>sim</sup></i>, but revertants of the gene did not. Interestingly, several mutations produced by excision partially complemented hybrid inviability, female sterility, or morphological anomalies. In the future, these mutations will be useful to further our understanding of the developmental mechanisms of reproductive isolation. Based on our analyses with the <i>Nup160<sup>sim</sup></i> introgression line, the lethal phase of hybrid inviability was determined to be during the early pupal stage. Our analysis also suggested that homozygous <i>Nup160<sup>sim</sup></i> in <i>D. melanogaster</i> leads to slow development. Thus, <i>Nup160<sup>sim</sup></i> is involved in multiple aspects of reproductive isolation between these two species.

Journal

  • Genes & Genetic Systems

    Genes & Genetic Systems 87(2), 99-106, 2012-04-25

    The Genetics Society of Japan

References:  29

Codes

  • NII Article ID (NAID)
    10030616563
  • NII NACSIS-CAT ID (NCID)
    AA11077421
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    13417568
  • NDL Article ID
    023672940
  • NDL Call No.
    Z53-W539
  • Data Source
    CJP  NDL  J-STAGE 
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