The inhibitory effects of heparin on the upper airway inflammation

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  • Ogawa Takao
    Department of Otorhinolaryngology, Shiga University of Medical Science
  • Shimizu Shino
    Department of Otorhinolaryngology, Shiga University of Medical Science
  • Tojima Ichiro
    Department of Otorhinolaryngology, Shiga University of Medical Science
  • Kouzaki Hideaki
    Department of Otorhinolaryngology, Shiga University of Medical Science
  • Shimizu Takeshi
    Department of Otorhinolaryngology, Shiga University of Medical Science

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  • 上気道炎症に対する新たな局所治療薬としてのヘパリンの可能性

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Abstract

Heparin is a member of a family of polyanionic polysaccharides called glycosaminoglycans, and is one of the most important anticoagulant drugs. Heparin also has a variety of anti-inflammatory functions, and is clinically used as an anti-inflammatory drug. In the lower airways, it has been reported that heparin attenuated eosinophil infiltration and Muc5ac mRNA expression in rat model of asthma, and inhaled heparin is effective for the treatment of patients with asthma. However, little is known about the regulatory effects of heparin on the upper airway inflammation. <br> We have examined the in vivo and in vitro effects of heparin on mucus hypersecretion in airway epithelial cells. Intranasal instillation with low-molecular-weight heparin (LMWH) or unfractionated heparin (UFH) significantly inhibited lipopolysaccharides (LPS)-induced and antigen-induced mucus hypersecretion in rat nasal epithelium. Mucosal infiltration of neutrophils and eosinophils were also significantly attenuated. The in vitro effects of heparin on secretion of mucin and cytokines were examined using cultured airway epithelial cells (NCI-H292). LMWH and UFH significantly inhibited TNF-α-induced secretion of mucin (MUC5AC) and IL-8. These results indicated that local administration with heparin may provide a new therapeutic strategy for upper airway inflammation.<br>

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