Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population

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Metabolic syndrome is defined as a cluster of multiple risk factors, including central obesity, dyslipidemia, hypertension and impaired glucose tolerance, that increase cardiovascular disease morbidity and mortality. Genetic factors are important in the development of metabolic syndrome, as are environmental factors. However, the genetic background of metabolic syndrome is not yet fully clarified. There is evidence that obesity and obesity-related phenotypes are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1. To investigate the relationship between metabolic syndrome and variations in these genes in the Japanese population, we genotyped 33 single-nucleotide polymorphisms (SNPs) in 19 genes from 1096 patients with metabolic syndrome and 581 control individuals who had no risk factors for metabolic syndrome. Four SNPs in the FTO gene were significantly related to metabolic syndrome: rs9939609 (P=0.00013), rs8050136 (P=0.00011), rs1558902 (P=6.6 × 10(-5)) and rs1421085 (P=7.4 × 10(-5)). rs3764220 in the SCG3 gene (P=0.0010) and rs2293855 in the MTMR9 gene (P=0.0015) were also significantly associated with metabolic syndrome. SNPs in the FTO, SCG3 and MTMR9 genes had no SNP × SNP epistatic effects on metabolic syndrome. Our data suggest that genetic variations in the FTO, SCG3 and MTMR9 genes independently influence the risk of metabolic syndrome.

収録刊行物

  • Journal of human genetics

    Journal of human genetics 56(9), 647-651, 2011-09-01

    Nature Publishing Group

参考文献:  31件中 1-31件 を表示

被引用文献:  1件中 1-1件 を表示

  • Genetic variations in the CYP17A1 and NT5C2 genes are associated with a reduction in visceral and subcutaneous fat areas in Japanese women

    HOTTA Kikuko , KITAMOTO Aya , KITAMOTO Takuya , MIZUSAWA Seiho , TERANISHI Hajime , MATSUO Tomoaki , NAKATA Yoshio , HYOGO Hideyuki , OCHI Hidenori , NAKAMURA Takahiro , KAMOHARA Seika , MIYATAKE Nobuyuki , KOTANI Kazuaki , KOMATSU Ryoya , ITOH Naoto , MINEO Ikuo , WADA Jun , YONEDA Masato , NAKAJIMA Atsushi , FUNAHASHI Tohru , MIYAZAKI Shigeru , TOKUNAGA Katsuto , MASUZAKI Hiroaki , UENO Takato , CHAYAMA Kazuaki , HAMAGUCHI Kazuyuki , YAMADA Kentaro , HANAFUSA Toshiaki , OIKAWA Shinichi , YOSHIMATSU Hironobu , SAKATA Toshiie , TANAKA Kiyoji , MATSUZAWA Yuji , NAKAO Kazuwa , SEKINE Akihiro

    Journal of human genetics 57(1), 46-51, 2012-01-01

    参考文献33件 被引用文献1件

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各種コード

  • NII論文ID(NAID)
    10030660817
  • NII書誌ID(NCID)
    AA11206160
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    14345161
  • NDL 記事登録ID
    11245368
  • NDL 雑誌分類
    ZS16(科学技術--医学--人類遺伝学)
  • NDL 請求記号
    Z54-H248
  • データ提供元
    CJP書誌  CJP引用  NDL  IR 
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