Possibility of Odontoblasts Activity Up-Regulation due to Orthodontic Mechanical Stress in Mice

DOI Web Site 5 Citations 19 References
  • Nakano Keisuke
    Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine
  • Muraoka Rina
    Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine
  • Tomida Mihoko
    Department of Oral Physiology, Matsumoto Dental University School of Dentistry
  • Matsuura Sachiko
    Department of Biology, Matsumoto Dental University School of Dentistry
  • Okafuji Norimasa
    Clinical Evaluation Unit, Matsumoto Dental University Graduate School of Oral Medicine
  • Chong Huat Siar
    Department of Oral Pathology, Oral Medicine & Periodontology, Faculty of Dentistry, University of Malaya
  • Kawakami Toshiyuki
    Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine

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Abstract

Using Waldo's method in mice, we examined the immunohistochemical expression of Runx2 and alkaline phosphatase (ALP) appearing in dental pulp cells, especially in odontoblasts, just after receiving experimental orthodontic mechanical stress, using Waldo's method in mice. The examination results demonstrated that some dental root pulp cells, especially some odontoblasts, expressed the Runx2 and ALP in a comparatively short time after receiving the stress. The results suggest that the stress may cause odontoblast activity up-regulation.

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