Effects of Functionally Graded Hydroxyapatite for Large Mandibular Defects in Adult Rabbits
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- Yoshimoto Ryota
- Division of Oral and Maxillofacial Surgery, Department of Dental Science, Institute of Personalized Medical Science, Health Sciences University of Hokkaido
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- Murata Masaru
- Oral and Maxillofacial Surgery, Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
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- Akazawa Toshiyuki
- Hokkaido Industrial Research Institute, School of Dentistry, Health Sciences University of Hokkaido
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- Arisue Makoto
- Oral and Maxillofacial Surgery, Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
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Objectives: As an alternative to autograft harvesting, we develop a functionally graded hydroxyapatite (fg-HAp) to induce bone regeneration within extensive bone defects. The functionally graded crystallinity from the inside layer to the surface layer of the fg-HAp promotes bone remodeling and replacement. We evaluate the effects of fg-HAp alone and in combination with fibroblast growth factor (bFGF) on bone regeneration within a bone defect in a rabbit mandible. <BR>Methods: The bone defect in the rabbit mandible was 12 x 9 x 3.5 mm in size. For the control group, no material was added to the defect. The experimental groups consisted of fg-HAp alone and fg-HAp combined with 5μg of bFGF. At 2, 4 and 8 weeks after implantation, we excised the mandibles and performed histomorphometrical analysis. <BR>Results: The fg-HAp resorption and replacement with new bone occurred fastest at the lingual portion of the defect. The fg-HAp maintained the mandibular outline and was absorbed by multinucleated giant cells. Blood vessel infiltration into the framework of fg-HAp was also observed. Adding 5μg of bFGF did not accelerate bone regeneration. The fg-HAp fragment was observed at the buccal portion of the defect. Excavated bone healing was observed only in the control group. <BR>Conclusions: The fg-HAp is an effective substrate for bone regeneration in critically sized bone defects.
収録刊行物
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- Journal of Hard Tissue Biology
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Journal of Hard Tissue Biology 19 (1), 33-42, 2010
硬組織再生生物学会
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詳細情報 詳細情報について
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- CRID
- 1390282679434803712
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- NII論文ID
- 130004480492
- 10030688314
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- NII書誌ID
- AA11074332
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- ISSN
- 1880828X
- 13417649
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- NDL書誌ID
- 10745172
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 抄録ライセンスフラグ
- 使用不可