Effects of Functionally Graded Hydroxyapatite for Large Mandibular Defects in Adult Rabbits
-
- Yoshimoto Ryota
- Division of Oral and Maxillofacial Surgery, Department of Dental Science, Institute of Personalized Medical Science, Health Sciences University of Hokkaido
-
- Murata Masaru
- Oral and Maxillofacial Surgery, Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
-
- Akazawa Toshiyuki
- Hokkaido Industrial Research Institute, School of Dentistry, Health Sciences University of Hokkaido
-
- Arisue Makoto
- Oral and Maxillofacial Surgery, Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
Search this article
Abstract
Objectives: As an alternative to autograft harvesting, we develop a functionally graded hydroxyapatite (fg-HAp) to induce bone regeneration within extensive bone defects. The functionally graded crystallinity from the inside layer to the surface layer of the fg-HAp promotes bone remodeling and replacement. We evaluate the effects of fg-HAp alone and in combination with fibroblast growth factor (bFGF) on bone regeneration within a bone defect in a rabbit mandible. <BR>Methods: The bone defect in the rabbit mandible was 12 x 9 x 3.5 mm in size. For the control group, no material was added to the defect. The experimental groups consisted of fg-HAp alone and fg-HAp combined with 5μg of bFGF. At 2, 4 and 8 weeks after implantation, we excised the mandibles and performed histomorphometrical analysis. <BR>Results: The fg-HAp resorption and replacement with new bone occurred fastest at the lingual portion of the defect. The fg-HAp maintained the mandibular outline and was absorbed by multinucleated giant cells. Blood vessel infiltration into the framework of fg-HAp was also observed. Adding 5μg of bFGF did not accelerate bone regeneration. The fg-HAp fragment was observed at the buccal portion of the defect. Excavated bone healing was observed only in the control group. <BR>Conclusions: The fg-HAp is an effective substrate for bone regeneration in critically sized bone defects.
Journal
-
- Journal of Hard Tissue Biology
-
Journal of Hard Tissue Biology 19 (1), 33-42, 2010
THE SOCIETY FOR HARD TISSUE REGENERATIVE BIOLOGY
- Tweet
Details 詳細情報について
-
- CRID
- 1390282679434803712
-
- NII Article ID
- 130004480492
- 10030688314
-
- NII Book ID
- AA11074332
-
- ISSN
- 1880828X
- 13417649
-
- NDL BIB ID
- 10745172
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed