Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Predicts Prognosis After Acute Coronary Syndrome : A Pilot Study

Access this Article

Search this Article

Author(s)

    • KUME Noriaki
    • Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
    • MITSUOKA Hirokazu
    • Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
    • HAYASHIDA Kazutaka
    • Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

Abstract

<b><i>Background:</i></b> Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is implicated in atherosclerotic plaque vulnerability. It is shed, in part, by proteases and released as soluble LOX-1 (sLOX-1), which is a specific and sensitive biomarker of acute coronary syndrome (ACS). The present study explored if sLOX-1 can also predict prognosis after ACS. <b><i>Methods and Results:</i></b> ACS patients undergoing emergency percutaneous coronary intervention and measurement of circulating sLOX-1 were followed (median: 896 days). Among 94 patients, 13 had ACS recurrence or died (re-ACS/death group). None of age, sex, lipid profile or prevalence of diabetes, smoking or hypertension was significantly different between the re-ACS/death group and the event-free survival group. Circulating sLOX-1 levels, but not those of high-sensitivity C-reactive protein (hs-CRP) or troponin T (TnT), were significantly (P<0.005) higher in the re-ACS/death group than in the event-free survival group. Kaplan-Meier survival curves showed that ACS patients with sLOX-1 values in the highest quartile or tertile had more frequent and earlier ACS recurrence or death. Receiver-operating characteristic curves for prediction of re-ACS or death showed higher sensitivity and specificity for sLOX-1 (area under the curve for sLOX-1, hs-CRP and TnT: 0.764, 0.658 and 0.524, respectively). <b><i>Conclusions:</i></b> Circulating sLOX-1, a diagnostic biomarker of ACS, also predicts ACS recurrence or death.  (<i>Circ J</i> 2010; <b>74:</b> 1399 - 1404)<br>

Journal

  • Circulation Journal

    Circulation Journal 74(7), 1399-1404, 2010-06-25

    The Japanese Circulation Society

References:  43

Cited by:  5

Codes

  • NII Article ID (NAID)
    10030695638
  • NII NACSIS-CAT ID (NCID)
    AA11591968
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13469843
  • Data Source
    CJP  CJPref  J-STAGE 
Page Top