Soluble lectin-like oxidized low-density lipoprotein receptor-1 predicts prognosis after acute coronary syndrome—a pilot study

• Kume Noriaki

  Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

• Mitsuoka Hirokazu

  Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

• Hayashida Kazutaka

  Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

• Tanaka Masaru

  Cardiovascular Center, Osaka Red Cross Hospital

• Kita Toru

  Director, Kobe Medical Center General Hospital

書誌事項

タイトル別名

• Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Predicts Prognosis After Acute Coronary Syndrome - A Pilot Study -
• – A Pilot Study –

抄録

Background: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is implicated in atherosclerotic plaque vulnerability. It is shed, in part, by proteases and released as soluble LOX-1 (sLOX-1), which is a specific and sensitive biomarker of acute coronary syndrome (ACS). The present study explored if sLOX-1 can also predict prognosis after ACS. Methods and Results: ACS patients undergoing emergency percutaneous coronary intervention and measurement of circulating sLOX-1 were followed (median: 896 days). Among 94 patients, 13 had ACS recurrence or died (re-ACS/death group). None of age, sex, lipid profile or prevalence of diabetes, smoking or hypertension was significantly different between the re-ACS/death group and the event-free survival group. Circulating sLOX-1 levels, but not those of high-sensitivity C-reactive protein (hs-CRP) or troponin T (TnT), were significantly (P<0.005) higher in the re-ACS/death group than in the event-free survival group. Kaplan-Meier survival curves showed that ACS patients with sLOX-1 values in the highest quartile or tertile had more frequent and earlier ACS recurrence or death. Receiver-operating characteristic curves for prediction of re-ACS or death showed higher sensitivity and specificity for sLOX-1 (area under the curve for sLOX-1, hs-CRP and TnT: 0.764, 0.658 and 0.524, respectively). Conclusions: Circulating sLOX-1, a diagnostic biomarker of ACS, also predicts ACS recurrence or death.  (Circ J 2010; 74: 1399 - 1404)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 74 (7), 1399-1404, 2010

  一般社団法人 日本循環器学会

キーワード

• Acute coronary syndrome
• Biomarkers
• Oxidative stress
• Plaque
• Prognosis

詳細情報

• CRID: 1390282680080032640
• NII論文ID: 10030695638
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-09-0924
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/74/7/74_CJ-09-0924/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010330228
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可