Human endogenous retrovirus K14C drove genomic diversification of the Y chromosome during primate evolution Human endogenous retrovirus K14C drove genomic diversification of the Y chromosome during primate evolution

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Author(s)

    • Sin Ho-Su SIN Ho-Su
    • Department of Integrative Cancer Therapy and Urology, Andrology Unit, Kanazawa University Graduate School of Medical Science
    • Koh Eitetsu KOH Eitetsu
    • Department of Integrative Cancer Therapy and Urology, Andrology Unit, Kanazawa University Graduate School of Medical Science
    • SUGIMOTO Kazuhiro
    • Department of Integrative Cancer Therapy and Urology, Andrology Unit, Kanazawa University Graduate School of Medical Science
    • MAEDA Yuji
    • Department of Integrative Cancer Therapy and Urology, Andrology Unit, Kanazawa University Graduate School of Medical Science
    • NAMIKI Mikio
    • Department of Integrative Cancer Therapy and Urology, Andrology Unit, Kanazawa University Graduate School of Medical Science

Abstract

金沢大学医薬保健研究域医学系The male-specific region of Y chromosome (MSY) has accumulated a higher density of human endogenous retroviruses (HERVs) and related sequences when compared with other regions of the human genome. Here, we focused on one HERV family, HERV-K14C that seemed to integrate preferentially into the Y chromosome in humans. To identify every copies of HERV-K14C in the human genome, we applied computational screening to map precisely the locus of individual HERV-K14C copies. Interestingly, 29 of all 146 copies were located in Y chromosome, and these 29 copies were mostly dispersed in the palindromic region. Three distinct HERV-K14C-related transcripts were found and were exclusively expressed in human testis tissue. Based on our phylogenetic analysis of the solitary LTRs derived from HERV-K14C on the Y chromosome we suggested that these sequences were generated as pairs of identical sequences. Specifically, analysis of HERV-K14C-related sequences in the palindromic region demonstrated that the Y chromosomal amplicons existed in our common ancestors and the duplicated pairs arose after divergence of great apes approximately 8-10 million years ago. Taken together, our observation suggested that HERV-K14C-related sequences contributed to genomic diversification of Y chromosome during speciation of great ape lineage. © 2010 The Japan Society of Human Genetics All rights reserved.出版社許諾要件により、2012年6月より全文公開.

Journal

  • Journal of human genetics

    Journal of human genetics 55(11), 717-725, 2010-11-01

    The Japan Society of Human Genetics = 日本人類遺伝学会

References:  36

Codes

  • NII Article ID (NAID)
    10030737445
  • NII NACSIS-CAT ID (NCID)
    AA11206160
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    14345161
  • NDL Article ID
    10885954
  • NDL Source Classification
    ZS16(科学技術--医学--人類遺伝学)
  • NDL Call No.
    Z54-H248
  • Data Source
    CJP  NDL  IR 
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