Structural Characteristics and Evolution of a Novel Venom Phospholipase A₂ Gene from Protobothrops flavoviridis Structural Characteristics and Evolution of a Novel Venom Phospholipase A_2 Gene from Protobothrops flavoviridis

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A novel phospholipase A<SUB>2</SUB> (PLA<SUB>2</SUB>) gene, named <I>PfPLA 6</I>, was found in a 6,328-bp NIS-1(5′)-a segment in the <I>Protobothrops flavoviridis</I> (Habu, Crotalinae) genome. A comparison of the aligned nucleotide sequences of Viperidae (Viperinae and Crotalinae) venom PLA<SUB>2</SUB> genes, including <I>PfPLA 6</I>, revealed the deletion of a 12-bp segment called S1EX 1 and a 55-bp segment called S2EX 1 in exon 1 and the interposition of a 219-bp segment called SINT 2 (SINE) in intron 2. A classification of Viperidae PLA<SUB>2</SUB> genes based on these structural modes indicated that the A-type genes (without SINE), including <I>PfPLA 6</I>, are evolutionarily ancestral to the B-type (Viperinae) and C-type (Crotalinae) PLA<SUB>2</SUB> genes (both with SINE). Since <I>PfPLA 6</I> is a pseudogene, an active prototype of <I>PfPLA 6</I> can be assumed to be the ancestral PLA<SUB>2</SUB> gene. Putative evolutionary processes from this A-type prototype PLA<SUB>2</SUB> gene to descendent PLA<SUB>2</SUB> genes are discussed.

収録刊行物

  • Bioscience, biotechnology, and biochemistry

    Bioscience, biotechnology, and biochemistry 76(3), 551-558, 2012-03-23

    公益社団法人 日本農芸化学会

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各種コード

  • NII論文ID(NAID)
    10030750784
  • NII書誌ID(NCID)
    AA10824164
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09168451
  • NDL 記事登録ID
    023553846
  • NDL 請求記号
    Z53-G223
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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