Anti-Aging Effects of Hesperidin on Saccharomyces cerevisiae via Inhibition of Reactive Oxygen Species and UTH1 Gene Expression

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This study used a replicative lifespan assay of K6001 yeast to screen anti-aging food factors in commercial flavonoids. Hesperidin derived from the <I>Citrus</I> genus extended the lifespan of yeast at doses of 5 and 10 μ<small>M</small> as compared with the control group (<I>p</I><0.01, <I>p</I><0.01). Reactive oxygen species (ROS), real-time PCR (RT-PCR), and lifespan assays of <I>uth1</I> and <I>skn7</I> mutants with the K6001 background were used to study the anti-aging mechanisms in yeast. The results indicate that hesperidin significantly inhibits the ROS of yeast, and <I>UTH1</I> gene expression, and that <I>SKN7</I> gene are involved in hesperidin-mediated lifespan extension. Further, increases in the Sir2 homolog, SIRT1 activity, and <I>SOD</I> gene expression were confirmed at doses of 5 (<I>p</I><0.01) and 10 μ<small>M</small> (<I>p</I><0.05). This suggests that <I>Sir2</I>, <I>UTH1</I> genes, and ROS inhibition after administration of hesperidin have important roles in the anti-aging effects of yeast. However, the aglycon hesperetin did not exhibit anti-aging effects in yeast.

収録刊行物

  • Bioscience, biotechnology, and biochemistry

    Bioscience, biotechnology, and biochemistry 76(4), 640-645, 2012-04-23

    公益社団法人 日本農芸化学会

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各種コード

  • NII論文ID(NAID)
    10030751227
  • NII書誌ID(NCID)
    AA10824164
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09168451
  • NDL 記事登録ID
    023592728
  • NDL 請求記号
    Z53-G223
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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