SHRSP/Izm and WKY/NCrlCrlj Rats Having a Missense Mutation in Abcg5 Deposited Plant Sterols in the Body, but Did Not Change Their Biliary Secretion and Lymphatic Absorption—Comparison with Jcl:Wistar and WKY/Izm Rats SHRSP/Izm and WKY/NCrlCrlj Rats Having a Missense Mutation in Abcg5 Deposited Plant Sterols in the Body, but Did Not Change Their Biliary Secretion and Lymphatic Absorption-Comparison with Jcl : Wistar and WKY/Izm Rats

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著者

    • KATO Masaki KATO Masaki
    • Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University
    • ITO Yusuke ITO Yusuke
    • Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School, Kyushu University
    • SATO Masao
    • Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School, Kyushu University
    • IMAIZUMI Katsumi
    • Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School, Kyushu University
    • INOUE Nao
    • Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University
    • IKEDA Ikuo
    • Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University

抄録

We had previously found plant sterols deposited in the bodies of stroke-prone spontaneously hypertensive rats (SHRSP)/Sea and Wistar Kyoto (WKY)/NCrlCrlj rats that had a missense mutation in the <I>Abcg5</I> cDNA sequence that coded for ATP-binding cassette transporter (ABC) G5. We used SHRSP/Izm, WKY/NCrlCrlj, and WKY/Izm rats in the present study to determine the mechanisms for plant sterol deposition in the body. Jcl:Wistar rats were used as a control strain. A diet containing 0.5% plant sterols fed to the rats resulted in plant sterol deposition in the body of SHRSP/Izm, but not in WKY/Izm or Jcl:Wistar rats. Only a single non-synonymous nucleotide change, G1747T, resulting in a conservative cysteine substitution for glycine at amino acid 583 (Gly583Cys) in <I>Abcg5</I> cDNA was identified in the SHRSP/Izm and WKY/NCrlCrlj rats. However, this mutation was not found in the WKY/Izm or Jcl:Wistar rats. No significant difference in the biliary secretion or lymphatic absorption of plant sterols was apparent between the rat strains with or without the missense mutation in <I>Abcg5</I> cDNA. Our observations suggest that plant sterol deposition in rat strains with the missense mutation in <I>Abcg5</I> cDNA can occur, despite there being no significant change in the biliary secretion or lymphatic absorption of plant sterols.

収録刊行物

  • Bioscience, biotechnology, and biochemistry

    Bioscience, biotechnology, and biochemistry 76(4), 660-664, 2012-04-23

    公益社団法人 日本農芸化学会

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各種コード

  • NII論文ID(NAID)
    10030751320
  • NII書誌ID(NCID)
    AA10824164
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09168451
  • NDL 記事登録ID
    023592848
  • NDL 請求記号
    Z53-G223
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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