Serum Cholesterol Reduction by Feeding a High-Cholesterol Diet Containing a Lower-Molecular-Weight Polyphenol Fraction from Peanut Skin

• TAMURA Tomoko

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

• INOUE Naoko

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

• SHIMIZU-IBUKA Akiko

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

• TADAISHI Miki

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

• TAKITA Toshichika

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

• ARAI Soichi

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

• MURA Kiyoshi

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

Abstract

Feeding a high-cholesterol diet with a water-soluble peanut skin polyphenol fraction to rats reduced their plasma cholesterol level, with an increase in fecal cholesterol excretion. The hypocholesterolemic effect was greater with the lower-molecular-weight rather than higher-molecular-weight polyphenol fraction. This effect was possibly due to some oligomeric polyphenols which reduced the solubility of dietary cholesterol in intestinal bile acid-emulsified micelles.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 76 (4), 834-837, 2012

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• peanut skin
• polyphenol
• cholesterol
• micelle solubility
• bile acid

Details

• CRID: 1390282681455270912
• NII Article ID: 10030752183
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.110866
• COI: 1:STN:280:DC%2BC38rjt1Witw%3D%3D
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 023593223
• PubMed: 22484944
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023593223
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.110866
• Web Site: https://search.jamas.or.jp/link/ui/2012264985
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed