Angelica keiskei Extract Improves Insulin Resistance and Hypertriglyceridemia in Rats Fed a High-Fructose Drink

• OHNOGI Hiromu

  Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Takara Bio Inc. Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Takara Bio Inc.

• HAYAMI Shoko

  Takara Bio Inc. Takara Bio Inc.

• KUDO Yoko

  Takara Bio Inc. Takara Bio Inc.

• DEGUCHI Suzu

  Takara Bio Inc. Takara Bio Inc.

• MIZUTANI Shigetoshi

  Takara Bio Inc. Takara Bio Inc.

• ENOKI Tatsuji

  Takara Bio Inc. Takara Bio Inc.

• TANIMURA Yuko

  Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine

• AOI Wataru

  Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Laboratory of Health Science, Kyoto Prefectural University Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Laboratory of Health Science, Kyoto Prefectural University

• NAITO Yuji

  Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine

• KATO Ikunoshin

  Takara Bio Inc. Takara Bio Inc.

• YOSHIKAWA Toshikazu

  Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine

書誌事項

タイトル別名

• <i>Angelica keiskei</i> Extract Improves Insulin Resistance and Hypertriglyceridemia in Rats Fed a High-Fructose Drink

抄録

Angelica keiskei is a traditional herb peculiar to Japan and abundantly contains vitamins, dietary fiber and such polyphenols as chalcone. We investigated in the present study the effect of A. keiskei on insulin resistance and hypertriglyceridemia in fructose-drinking rats as a model for the metabolic syndrome. Male Wistar rats were given a 15% fructose solution as drinking water for 11 weeks. Fructose significantly increased the levels of serum insulin and triglyceride (TG) compared with the control level. Treatment with an ethanol extract of A. keiskei (AE) significantly reduced the levels of blood glucose (−16.5%), serum insulin (−47.3%), HOMA-R (−56.4%) and TG (−24.2%). A hepatic gene analysis showed that fructose reduced the expression of the genes related to fatty acid β-oxidation and high-density lipoprotein (HDL) production. Treatment with AE enhanced the expression of the acyl-CoA oxidase 1 (ACO1), medium-chain acyl-CoA dehydrogenase (MCAD), ATP-binding membrane cassette transporter A1 (ABCA1) and apolipoprotein A1 (Apo-A1) genes. These results suggest that AE improved the insulin resistance and hypertriglyceridemia of the fructose-drinking rats.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 76 (5), 928-932, 2012

  公益社団法人 日本農芸化学会

キーワード

• <i>Angelica keiskei</i>
• insulin resistance
• hypertriglyceridemia
• fructose-drinking rat

詳細情報

• CRID: 1390282681454329600
• NII論文ID: 10030752696
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.110927
• COI: 1:STN:280:DC%2BC38jltlOgtA%3D%3D
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 023681891
• PubMed: 22738961
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023681891
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.110927
• Web Site: https://search.jamas.or.jp/link/ui/2013092408
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可