Aleuria aurantia Lectin Exhibits Antifungal Activity against Mucor racemosus

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<i>Aleuria aurantia</i> lectin (AAL) is an <small>L</small>-fucose-specific lectin produced in the mycelia and fruit-bodies of the widespread ascomycete fungus <i>Aleuria aurantia</i>. It is extensively used in the detection of fucose, but its physiological role remains unknown. To investigate this, we analyzed the interaction between AAL and, a zygomycete fungus <i>Mucor racemosus</i>, which is assumed to contain fucose in its cell wall. AAL specifically bound to the hyphae of <i>M. racemosus</i>, because binding was inhibited by <small>L</small>-fucose but not by <small>D</small>-fucose. It inhibited the growth of the fungus at 1 µ<small>M</small>, and the <i>M. racemosus</i> cells were remarkably disrupted at 7.5 µ<small>M</small>. In contrast, two other fucose-specific lectins, <i>Anguilla anguilla</i> agglutinin and <i>Ulex europaeus</i> agglutinin, did not inhibit the growth of <i>M. racemosus</i>. These results suggest that the growth inhibition activity is unique to AAL, and that AAL could act as an antifungal protein in natural ecosystems.

収録刊行物

  • Bioscience, biotechnology, and biochemistry

    Bioscience, biotechnology, and biochemistry 76(5), 967-970, 2012-05-23

    Japan Society for Bioscience, Biotechnology, and Agrochemistry

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各種コード

  • NII論文ID(NAID)
    10030752918
  • NII書誌ID(NCID)
    AA10824164
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09168451
  • NDL 記事登録ID
    023681942
  • NDL 請求記号
    Z53-G223
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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